NP_057427.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
367,764 Da
NCBI Official Full Name
Homo sapiens centromere protein F, 350/400kDa (CENPF), mRNA
NCBI Official Synonym Full Names
centromere protein F, 350/400kDa
NCBI Protein Information
centromere protein F; AH antigen; CENP-F kinetochore protein; cell-cycle-dependent 350K nuclear protein; centromere protein F, 350/400kDa (mitosin); centromere protein F, 350/400ka (mitosin); kinetochore protein CENPF
UniProt Protein Name
Centromere protein F
UniProt Synonym Protein Names
AH antigen; Kinetochore protein CENPF; Mitosin
UniProt Entry Name
CENPF_HUMAN
NCBI Summary for CENPF
This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]
UniProt Comments for CENPF
CENPF: a nuclear matrix protein that assembles onto kinetochores at late G2. Is hyperphosphorylated during mitosis and rapidly degraded after mitosis. Involved in chromosome segregation during mitosis. Interacts with retinoblastoma protein (RB), CENP-E and BUBR1. Two alternatively spliced human isoforms have been described.
Protein type: Nuclear envelope; Cell cycle regulation; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: spindle pole; nuclear matrix; pronucleus; nuclear envelope; cytosol; nucleoplasm; kinetochore; perinuclear region of cytoplasm; cytoplasm; outer kinetochore of condensed chromosome; spindle; midbody; chromatin; nucleus; chromosome, pericentric region
Molecular Function: protein C-terminus binding; dynein binding; protein binding; protein homodimerization activity; chromatin binding; transcription factor binding
Biological Process: response to drug; mitosis; kinetochore assembly; muscle development; regulation of cell cycle; chromosome segregation; cell proliferation; protein transport; cell division; mitotic cell cycle spindle assembly checkpoint; regulation of G2/M transition of mitotic cell cycle; metaphase plate congression; mitotic cell cycle; cell differentiation; negative regulation of transcription, DNA-dependent; G2/M transition of mitotic cell cycle; regulation of striated muscle development
Disease: Ciliary Dyskinesia, Primary, 31
Research Articles on CENPF
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Products associated with anti-CENPF antibody
Pathways associated with anti-CENPF antibody
Diseases associated with anti-CENPF antibody
Organs/Tissues associated with anti-CENPF antibody
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