NP_001284.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,215 Da
NCBI Official Full Name
Homo sapiens chloride channel, nucleotide-sensitive, 1A (CLNS1A), mRNA
NCBI Official Synonym Full Names
chloride channel, nucleotide-sensitive, 1A
NCBI Protein Information
methylosome subunit pICln; chloride channel regulatory protein; chloride channel, nucleotide sensitive 1A; chloride conductance regulatory protein ICln; chloride ion current inducer protein; i(Cln); reticulocyte pICln; reticulocyte protein ICln
UniProt Protein Name
Methylosome subunit pICln
UniProt Synonym Protein Names
Chloride channel, nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; I(Cln); Chloride ion current inducer protein; ClCI; Reticulocyte pICln
UniProt Entry Name
ICLN_HUMAN
NCBI Summary for CLNS1A
This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. [provided by RefSeq, Feb 2009]
UniProt Comments for CLNS1A
ICLN: The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. Belongs to the pICln (TC 1.A.47) family.
Protein type: Channel, chloride
Chromosomal Location of Human Ortholog: 11q13.5-q14
Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; plasma membrane; nucleus; cytosol
Molecular Function: protein binding
Biological Process: spliceosomal snRNP biogenesis; chloride transport; gene expression; cell volume homeostasis
Research Articles on CLNS1A
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Products associated with anti-CLNS1A antibody
Pathways associated with anti-CLNS1A antibody
Diseases associated with anti-CLNS1A antibody
Organs/Tissues associated with anti-CLNS1A antibody
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