Q7LDD5
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UniProt Related Accession #
NCBI Official Full Name
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, isoform CRA_b
NCBI Official Synonym Full Names
calcium/calmodulin-dependent protein kinase II alpha
NCBI Protein Information
calcium/calmodulin-dependent protein kinase type II subunit alpha; CaMKIINalpha; OTTHUMP00000165787; OTTHUMP00000165788; CaMK-II alpha subunit; caMK-II subunit alpha; CaM-kinase II alpha chain; CaM kinase II alpha subunit; caM kinase II subunit alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
UniProt Protein Name
Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, isoform CRA_a
UniProt Entry Name
Q7LDD5_HUMAN
NCBI Summary for CAMK2A
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
UniProt Comments for CAMK2A
CAMK2A: a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.17; Protein kinase, CAMK; Kinase, protein; CAMK group; CAMK2 family
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: nucleoplasm; presynaptic membrane; mitochondrion; plasma membrane; cytosol; nucleus; cell junction
Molecular Function: calmodulin binding; protein serine/threonine kinase activity; protein binding; glutamate receptor binding; protein homodimerization activity; calmodulin-dependent protein kinase activity; kinase activity; ATP binding
Biological Process: synaptic transmission; peptidyl-serine phosphorylation; calcium ion transport; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; regulation of neurotransmitter secretion; positive regulation of calcium ion transport; protein amino acid phosphorylation; regulation of neuronal synaptic plasticity; activation of NF-kappaB transcription factor; G1/S transition of mitotic cell cycle
Research Articles on CAMK2A
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Products associated with anti-CAMK2A antibody
Pathways associated with anti-CAMK2A antibody
Diseases associated with anti-CAMK2A antibody
Organs/Tissues associated with anti-CAMK2A antibody
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