NP_005198.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
crk-like protein
NCBI Official Synonym Full Names
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
NCBI Official Synonym Symbols
NCBI Protein Information
crk-like protein; OTTHUMP00000198538; OTTHUMP00000198539
UniProt Protein Name
Crk-like protein
UniProt Entry Name
CRKL_HUMAN
NCBI Summary for CRKL
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
UniProt Comments for CRKL
CRKL: an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: cytosol; endosome
Molecular Function: protein binding; signal transducer activity; SH3/SH2 adaptor activity
Biological Process: anterior/posterior pattern formation; blood vessel development; organ morphogenesis; nerve growth factor receptor signaling pathway; thymus development; activation of MAPKK activity; heart development; Ras protein signal transduction; JNK cascade; parathyroid gland development
Research Articles on CRKL
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Products associated with anti-CRKL antibody
Pathways associated with anti-CRKL antibody
Diseases associated with anti-CRKL antibody
Disease Name |
Pubmed Publications |
Leukemia Antibodies |
>114 publications with CRKL and Leukemia |
Neoplasms Antibodies |
>113 publications with CRKL and Neoplasms |
Leukemia, Myeloid Antibodies |
>86 publications with CRKL and Leukemia, Myeloid |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies |
>69 publications with CRKL and Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
Cell Transformation, Neoplastic Antibodies |
>26 publications with CRKL and Cell Transformation, Neoplastic |
Leukemia, Myeloid, Acute Antibodies |
>10 publications with CRKL and Leukemia, Myeloid, Acute |
Abnormalities, Multiple Antibodies |
>8 publications with CRKL and Abnormalities, Multiple |
Heart Defects, Congenital Antibodies |
>8 publications with CRKL and Heart Defects, Congenital |
Craniofacial Abnormalities Antibodies |
>8 publications with CRKL and Craniofacial Abnormalities |
DiGeorge Syndrome Antibodies |
>8 publications with CRKL and DiGeorge Syndrome |
Organs/Tissues associated with anti-CRKL antibody
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