AAB35516.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
fatty acid synthase
NCBI Official Synonym Full Names
fatty acid synthase
NCBI Official Synonym Symbols
FAS; OA-519; SDR27X1; MGC14367; MGC15706 [Similar Products]
NCBI Protein Information
fatty acid synthase; short chain dehydrogenase/reductase family 27X, member 1
UniProt Protein Name
Fatty acid synthase
UniProt Synonym Gene Names
UniProt Entry Name
FAS_HUMAN
NCBI Summary for FASN
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq]
UniProt Comments for FASN
FASN: a multifunctional enzyme. Catalyzes the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
Protein type: EC 1.3.1.39; Lyase; EC 2.3.1.85; Oxidoreductase; Hydrolase; Acetyltransferase; EC 2.3.1.41; EC 1.1.1.100; EC 2.3.1.39; EC 4.2.1.59; Lipid Metabolism - fatty acid biosynthesis; EC 2.3.1.38; EC 3.1.2.14
Chromosomal Location of Human Ortholog: 17q25
Cellular Component: Golgi apparatus; glycogen granule; mitochondrion; membrane; cytoplasm; melanosome; plasma membrane; cytosol
Molecular Function: protein homodimerization activity; fatty-acid synthase activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; zinc ion binding; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; [acyl-carrier-protein] S-acetyltransferase activity; drug binding; 3-oxoacyl-[acyl-carrier-protein] reductase activity; protein binding; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; [acyl-carrier-protein] S-malonyltransferase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
Biological Process: osteoblast differentiation; vitamin metabolic process; acetyl-CoA metabolic process; pantothenate metabolic process; positive regulation of cellular metabolic process; energy reserve metabolic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; fatty acid metabolic process; water-soluble vitamin metabolic process; fatty acid biosynthetic process
Research Articles on FASN
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Pathways associated with anti-FASN antibody
Diseases associated with anti-FASN antibody
Organs/Tissues associated with anti-FASN antibody
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