NP_006109
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,801 Da
NCBI Official Full Name
HCLS1-associated protein X-1 isoform a
NCBI Official Synonym Full Names
HCLS1 associated protein X-1
NCBI Protein Information
HCLS1-associated protein X-1
UniProt Protein Name
HCLS1-associated protein X-1
UniProt Synonym Protein Names
HS1-associating protein X-1; HAX-1; HS1-binding protein 1; HSP1BP-1
UniProt Synonym Gene Names
NCBI Summary for HAX1
The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for HAX1
Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.
Product References and Citations for anti-HAX1 antibody
Klein C, et al., (2007) Nat Genet. 39 (1):86-92; Yin H, et al., (2001) Cytokine. 15 (3):122-37
Research Articles on HAX1
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Products associated with anti-HAX1 antibody
Diseases associated with anti-HAX1 antibody
Organs/Tissues associated with anti-HAX1 antibody
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