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Add To Compare List anti-HBEGF antibody :: Mouse anti-Human Heparin Binding EGF-like Growth Factor Monoclonal Antibody Catalog # MBS603983 Unit / Price 0.1 mg / $995 +1 FREE 8GB USB 5x0.1 mg / $4,300 +5 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Heparin Binding EGF-like Growth Factor (HBEGF), Monoclonal Antibody Popular Item Full Product Name Heparin Binding EGF-like Growth Factor (HB-EGF, HBEGF, Diphtheria Toxin Receptor, DT-R, DTR) Product Synonym Names Anti -Heparin Binding EGF-like Growth Factor (HB-EGF, HBEGF, Diphtheria Toxin Receptor, DT-R, DTR) Product Gene Name anti-HBEGF antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Chromosome Location Chromosome: 5; NC_000005.9 (139712428..139726188, complement). Location: 5q23 OMIM 126150 3D Structure ModBase 3D Structure for Q99075 Clonality Monoclonal Isotype IgG2a Clone Number 7H229 Host Mouse Species Reactivity Human Specificity Recognizes human Heparin Binding EGF-like Growth Factor (HB-EGF). Does not crossreact with recombinant human Amphiregulin, BTC, HRG-alpha, HRG-beta, EGF, TGF-alpha or recombinant mouse Epigen or Epiregulin. Purity/Purification Affinity PurifiedPurified by Protein G affinity chromatography. Form/Format Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 1ml sterile PBS. Concentration ~0.5 mg/ml (after reconstitution) (lot specific) Immunogen Recombinant protein corresponding to aa63-148 of human HB-EGF expressed in Sf21. Species Sequence Homology (77%): rat and mouse Endotoxin Level <0.1EU/ug (LAL). Preparation and Storage Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Other Notes Small volumes of anti-HBEGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-HBEGF antibody Heparin-binding EGF-like Growth Factor (HB-EGF) is an EGF family growth factor that is synthesized as a transmembrane precursor (proHB-EGF). ProHB-EGF, which contains one EGF-like domain, is subject to variable O-linked glycosylation and N-terminal truncation. In human, this precursor is the cellular receptor for diphtheria toxin. ADAM12 or ADAM17-mediated cleavage of proHB-EGF releases a 22 kD soluble HB-EGF; the cytoplasmic fragment functions as a transcriptional repressor. HB-EGF directly activates EGF R and ErbB4 and promotes the development of many tissues. Human HB-EGF shares 77% aa sequence identity with mouse and rat HB-EGF. Product Categories/Family for anti-HBEGF antibody Antibodies; Abs to Growth Factors; Cytokines Applications Tested/Suitable for anti-HBEGF antibody ELISA (EL/EIA), Western Blot (WB), Neutralization Application Notes for anti-HBEGF antibody Suitable for use in Western Blot, Neutralization and ELISA.Dilution: Western Blot: 1ug/ml using recombinant human Heparin Binding EGF-like Growth Factor.Neutralization: ~0.5-2.5ug/ml yields one-half maximal inhibition (ND50) of the biological activity of recombinant human HB-EGF (5ng/ml). Measured by its ability to neutralize HB-EGF-induced proliferation in the Balb/3T3 mouse embryonic fibroblast cell line. TOP NCBI/Uniprot data below describe general gene information for HBEGF. It may not necessarily be applicable to this product. NCBI GI # 183867 NCBI GeneID 1839 UniProt Primary Accession # Q99075 [Other Products] UniProt Secondary Accession # B2R821[Other Products] UniProt Related Accession # Q14487; Q53H93; Q99075; Q9UMJ6[Other Products] Molecular Weight 23,067 Da[Similar Products] TOP NCBI Official Full Name heparin-binding EGF-like growth factor NCBI Official Synonym Full Names heparin-binding EGF-like growth factor NCBI Official Symbol HBEGF [Similar Products] NCBI Official Synonym Symbols DTR; DTS; DTSF; HEGFL [Similar Products] NCBI Protein Information proheparin-binding EGF-like growth factor; OTTHUMP00000159876; heparin-binding epidermal growth factor; diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) UniProt Protein Name Proheparin-binding EGF-like growth factor UniProt Synonym Protein Names Diphtheria toxin receptor Protein Family Proheparin-binding EGF-like growth factor UniProt Gene Name HBEGF [Similar Products] UniProt Synonym Gene Names DTR; DTS; HEGFL [Similar Products] UniProt Entry Name HBEGF_HUMAN TOP TOP UniProt Comments for HBEGF HBEGF: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.Protein type: Membrane protein, integral; Cell surfaceChromosomal Location of Human Ortholog: 5q23Cellular Component: extracellular space; cell surface; integral to plasma membrane; plasma membrane; extracellular regionMolecular Function: heparin binding; growth factor activity; epidermal growth factor receptor bindingBiological Process: epidermal growth factor receptor signaling pathway; positive regulation of keratinocyte migration; muscle development; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; positive regulation of smooth muscle cell proliferation; negative regulation of elastin biosynthetic process; pathogenesis; signal transduction; positive regulation of cell growth; regulation of heart contraction; positive regulation of protein kinase B signaling cascade; positive regulation of cell proliferation; innate immune response; wound healing, spreading of epidermal cells; positive regulation of cell migration Research Articles on HBEGF 1. ATP induces HB-EGF synthesis and release by interacting with the P2 purinergic receptor and through p38 and ERK1/2 signaling in response to a challenging environment. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-HBEGF antibody Reference Product PubMed Publications EGFR antibody >13 publications with HBEGF and EGFR ERBB4 antibody >4 publications with HBEGF and ERBB4 MMP7 antibody >2 publications with HBEGF and MMP7 CD44 antibody >1 publications with HBEGF and CD44 Pathways associated with anti-HBEGF antibody Products by Pathway Pathway Diagram Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram ErbB Receptor Signaling Network Pathway antibodies ErbB Receptor Signaling Network Pathway Diagram ErbB Signaling Pathway antibodies ErbB Signaling Pathway Diagram ErbB Signaling Pathway antibodies ErbB Signaling Pathway Diagram ErbB Signaling Pathway antibodies ErbB Signaling Pathway Diagram ErbB4 Signaling Events Pathway antibodies ErbB4 Signaling Events Pathway Diagram GnRH Signaling Pathway antibodies GnRH Signaling Pathway Diagram GnRH Signaling Pathway antibodies GnRH Signaling Pathway Diagram Hypertrophy Model Pathway antibodies Hypertrophy Model Pathway Diagram Diseases associated with anti-HBEGF antibody Disease Name Pubmed Publications Neoplasms Antibodies >7 publications with HBEGF and Neoplasms Cardiovascular Diseases Antibodies >7 publications with HBEGF and Cardiovascular Diseases Inflammation Antibodies >6 publications with HBEGF and Inflammation Vascular Diseases Antibodies >5 publications with HBEGF and Vascular Diseases Heart Diseases Antibodies >4 publications with HBEGF and Heart Diseases Carcinoma Antibodies >3 publications with HBEGF and Carcinoma Colorectal Neoplasms Antibodies >3 publications with HBEGF and Colorectal Neoplasms Drug Toxicity Antibodies >3 publications with HBEGF and Drug Toxicity Lung Diseases Antibodies >3 publications with HBEGF and Lung Diseases Neoplasm Metastasis Antibodies >2 publications with HBEGF and Neoplasm Metastasis Organs/Tissues associated with anti-HBEGF antibody Organ/Tissue Name Pubmed Publications Placenta Antibodies >9 publications with HBEGF and Placenta Lung Antibodies >8 publications with HBEGF and Lung Vascular Antibodies >7 publications with HBEGF and Vascular Muscle Antibodies >7 publications with HBEGF and Muscle Embryonic Tissue Antibodies >6 publications with HBEGF and Embryonic Tissue Uterus Antibodies >6 publications with HBEGF and Uterus Blood Antibodies >5 publications with HBEGF and Blood Skin Antibodies >4 publications with HBEGF and Skin Heart Antibodies >3 publications with HBEGF and Heart Liver Antibodies >3 publications with HBEGF and Liver TOP © 2006-24 MyBioSource.com. 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