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Add To Compare List anti-IGFBP4 antibody :: Mouse IGFBP4 Monoclonal Antibody Catalog # MBS838049 Unit / Price 0.5 mg / $660 +1 FREE 8GB USB 5x0.5 mg / $2,780 +3 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name IGFBP4, Monoclonal Antibody Full Product Name IGFBP4 antibody Product Synonym Names Monoclonal IGFBP4; Anti-IGFBP4; Insulin Growth Factor Binding Protein 4; IGFBP-4; IGFBP 4 Product Gene Name anti-IGFBP4 antibody[Similar Products] Matching Pairs Capture Antibody: IGFBP4 Clone #M18612IG3 (MBS838049)Detection Antibody: IGFBP4 Clone #M18612IG4 (MBS838085)Comments: For use in sandwich immunoassay Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM 146733 Clonality Monoclonal Isotype IgG2b Clone Number M18612IG3 Host Mouse Specificity Human IGFBP-4 Purity/Purification IGFBP-4 antibody was purified by Protein A chromatography. Form/Format Supplied in PBS, pH 7.4, 0.1 % sodium azide (NaN3) Biological Significance IGFBP-4 binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. It is secreted by all colon cancer cells. Biohazard Information This product is sold as an antibody preparation for research use only. Standard Laboratory Practices should be followed when handling this material. Contains sodium azide (0.1 %) as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen IGFBP-4 antibody was raised in mouse using recombinant IGFBP-4 expressed in human cell line as the immunogen. Preparation and Storage Store at 4 degree C Other Notes Small volumes of anti-IGFBP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-IGFBP4 antibody Mouse monoclonal IGFBP-4 antibody Product Categories/Family for anti-IGFBP4 antibody Cell Biology Applications Tested/Suitable for anti-IGFBP4 antibody ELISA (EIA), Immunoassays Application Notes for anti-IGFBP4 antibody MBS838049 can be used in a sandwich immunoassay as a coating antibody in conjunction with MBS838085 as the conjugate antibody TOP NCBI/Uniprot data below describe general gene information for IGFBP4. It may not necessarily be applicable to this product. NCBI GI # 62243290 NCBI GeneID 3487 NCBI Accession # NP_001543.2 [Other Products] NCBI GenBank Nucleotide # NM_001552.2 [Other Products] UniProt Secondary Accession # Q5U012; Q9UCL6; A0N9W2; B4E351[Other Products] UniProt Related Accession # P22692[Other Products] Molecular Weight 17,635 Da TOP NCBI Official Full Name insulin-like growth factor-binding protein 4 NCBI Official Synonym Full Names insulin-like growth factor binding protein 4 NCBI Official Symbol IGFBP4 [Similar Products] NCBI Official Synonym Symbols BP-4; IBP4; IGFBP-4; HT29-IGFBP [Similar Products] NCBI Protein Information insulin-like growth factor-binding protein 4 UniProt Protein Name Insulin-like growth factor-binding protein 4 Protein Family Insulin-like growth factor-binding protein UniProt Gene Name IGFBP4 [Similar Products] UniProt Synonym Gene Names IBP4; IBP-4; IGF-binding protein 4; IGFBP-4 [Similar Products] UniProt Entry Name IBP4_HUMAN TOP NCBI Summary for IGFBP4 This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008] TOP UniProt Comments for IGFBP4 IGFBP4: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 17q21.2Cellular Component: extracellular space; extracellular regionMolecular Function: insulin-like growth factor I binding; insulin-like growth factor II bindingBiological Process: positive regulation of insulin-like growth factor receptor signaling pathway; cell proliferation; cellular protein metabolic process; regulation of insulin-like growth factor receptor signaling pathway; positive regulation of MAPKKK cascade; regulation of cell growth; inflammatory response; signal transduction; DNA metabolic process; skeletal development Research Articles on IGFBP4 1. IGF-1/IGFbp4 signaling regulated the post-developmental adipose tissue expansion. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-IGFBP4 antibody Reference Product PubMed Publications IGFBP1 antibody >150 publications with IGFBP4 and IGFBP1 IGF1 antibody >26 publications with IGFBP4 and IGF1 IGF2 antibody >20 publications with IGFBP4 and IGF2 PTH antibody >18 publications with IGFBP4 and PTH PAPPA antibody >9 publications with IGFBP4 and PAPPA IL6 antibody >2 publications with IGFBP4 and IL6 WNT3A antibody >2 publications with IGFBP4 and WNT3A PAPPA2 antibody >2 publications with IGFBP4 and PAPPA2 LRP6 antibody >1 publications with IGFBP4 and LRP6 Pathways associated with anti-IGFBP4 antibody Products by Pathway Pathway Diagram Metabolism Of Proteins Pathway antibodies Metabolism Of Proteins Pathway Diagram Myometrial Relaxation And Contraction Pathways antibodies Myometrial Relaxation And Contraction Pathways Diagram Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram Wnt Signaling Network Pathway antibodies Wnt Signaling Network Pathway Diagram Diseases associated with anti-IGFBP4 antibody Disease Name Pubmed Publications Carcinoma Antibodies >48 publications with IGFBP4 and Carcinoma Breast Neoplasms Antibodies >29 publications with IGFBP4 and Breast Neoplasms Hypertrophy Antibodies >26 publications with IGFBP4 and Hypertrophy Adenocarcinoma Antibodies >21 publications with IGFBP4 and Adenocarcinoma Nervous System Diseases Antibodies >20 publications with IGFBP4 and Nervous System Diseases Inflammation Antibodies >20 publications with IGFBP4 and Inflammation Necrosis Antibodies >20 publications with IGFBP4 and Necrosis Kidney Diseases Antibodies >19 publications with IGFBP4 and Kidney Diseases Weight Loss Antibodies >15 publications with IGFBP4 and Weight Loss Prostatic Neoplasms Antibodies >14 publications with IGFBP4 and Prostatic Neoplasms Organs/Tissues associated with anti-IGFBP4 antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >199 publications with IGFBP4 and Blood Bone Antibodies >110 publications with IGFBP4 and Bone Muscle Antibodies >108 publications with IGFBP4 and Muscle Ovary Antibodies >104 publications with IGFBP4 and Ovary Liver Antibodies >75 publications with IGFBP4 and Liver Vascular Antibodies >67 publications with IGFBP4 and Vascular Connective Tissue Antibodies >54 publications with IGFBP4 and Connective Tissue Kidney Antibodies >54 publications with IGFBP4 and Kidney Brain Antibodies >41 publications with IGFBP4 and Brain Embryonic Tissue Antibodies >33 publications with IGFBP4 and Embryonic Tissue TOP © 2006-24 MyBioSource.com. 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