NP_005919.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,523 Da
NCBI Official Full Name
lactadherin isoform a preproprotein
NCBI Official Synonym Full Names
milk fat globule-EGF factor 8 protein
NCBI Official Synonym Symbols
BA46; HMFG; MFGM; SED1; hP47; EDIL1; MFG-E8; SPAG10; OAcGD3S; HsT19888 [Similar Products]
NCBI Protein Information
lactadherin; medin; sperm surface protein hP47; sperm associated antigen 10; breast epithelial antigen BA46; O-acetyl disialoganglioside synthase
UniProt Protein Name
Lactadherin
UniProt Synonym Protein Names
Breast epithelial antigen BA46; HMFG; MFGM; Milk fat globule-EGF factor 8; MFG-E8; SED1Cleaved into the following 2 chains:Lactadherin short form; Medin
UniProt Synonym Gene Names
UniProt Entry Name
MFGM_HUMAN
NCBI Summary for MFGE8
This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
UniProt Comments for MFGE8
MFGE8: Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 15q25
Cellular Component: extrinsic to plasma membrane; extracellular matrix; extracellular space; membrane; extracellular region; vesicle; external side of plasma membrane
Molecular Function: integrin binding; phosphatidylethanolamine binding; phosphatidylserine binding
Biological Process: viral reproduction; single fertilization; phagocytosis, recognition; angiogenesis; cell adhesion; phagocytosis, engulfment
Research Articles on MFGE8
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Products associated with anti-MFGE8 antibody
Pathways associated with anti-MFGE8 antibody
Diseases associated with anti-MFGE8 antibody
Organs/Tissues associated with anti-MFGE8 antibody
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