EAW94677.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,183 Da
NCBI Official Full Name
nerve growth factor receptor (TNFR superfamily, member 16)
NCBI Official Synonym Full Names
nerve growth factor receptor
NCBI Official Synonym Symbols
CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 16; p75 ICD; NGF receptor; TNFR superfamily, member 16; low affinity nerve growth factor receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 16
UniProt Synonym Protein Names
Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD
UniProt Synonym Gene Names
UniProt Entry Name
TNR16_HUMAN
NCBI Summary for NGFR
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]
UniProt Comments for NGFR
Function: Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake
By similarity. Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Ref.11
Subunit structure: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts (via death domain) with RAB31
By similarity. Interacts with LINGO1. Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11
Subcellular location: Membrane; Single-pass type I membrane protein.
Domain: Death domain is responsible for interaction with RANBP9.The extracellular domain is responsible for interaction with NTRK1
By similarity.
Post-translational modification: N- and O-glycosylated. Ref.12O-linked glycans consist of Gal1-3GalNAc core elongated by 1 or 2 NeuNAc.Phosphorylated on serine residues.
Sequence similarities: Contains 1 death domain.Contains 4 TNFR-Cys repeats.
Research Articles on NGFR
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Pathways associated with anti-NGFR antibody
Diseases associated with anti-NGFR antibody
Organs/Tissues associated with anti-NGFR antibody
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