P20783
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
nerve growth factor
NCBI Official Synonym Full Names
neurotrophin 3
NCBI Official Synonym Symbols
NT3; HDNF; NGF2; NGF-2; MGC129711 [Similar Products]
NCBI Protein Information
neurotrophin-3; NT-3; OTTHUMP00000239132; OTTHUMP00000239133; neurotrophic factor; nerve growth factor 2
UniProt Protein Name
Neurotrophin-3
UniProt Synonym Protein Names
HDNF; Nerve growth factor 2; NGF-2; Neurotrophic factor
UniProt Entry Name
NTF3_HUMAN
NCBI Summary for NTF3
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq]
UniProt Comments for NTF3
NT-3: Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Cytokine; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: cytoplasmic membrane-bound vesicle; extracellular region
Molecular Function: neurotrophin p75 receptor binding; growth factor activity; nerve growth factor binding; receptor binding; chemoattractant activity
Biological Process: myelination; axon guidance; mechanoreceptor differentiation; epidermis development; glial cell fate determination; regulation of neuron differentiation; activation of MAPK activity; positive regulation of receptor internalization; positive regulation of glial cell differentiation; signal transduction; enteric nervous system development; induction of positive chemotaxis; positive chemotaxis; cell-cell signaling; positive regulation of cell proliferation; negative regulation of neuron apoptosis; regulation of synaptic transmission; negative regulation of peptidyl-tyrosine phosphorylation; nervous system development; activation of protein kinase B; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; neuromuscular synaptic transmission; smooth muscle cell differentiation; nerve development; positive regulation of transcription from RNA polymerase II promoter; brain development; transmembrane receptor protein tyrosine kinase signaling pathway; neurite morphogenesis; positive regulation of cell migration
Research Articles on NTF3
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Products associated with anti-NTF3 antibody
Pathways associated with anti-NTF3 antibody
Diseases associated with anti-NTF3 antibody
Organs/Tissues associated with anti-NTF3 antibody
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