AAA36380.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
nucleophosmin
NCBI Official Synonym Full Names
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NCBI Official Synonym Symbols
NCBI Protein Information
nucleophosmin
UniProt Protein Name
Nucleophosmin
UniProt Synonym Protein Names
Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin
UniProt Synonym Gene Names
UniProt Entry Name
NPM_HUMAN
NCBI Summary for NPM1
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
UniProt Comments for NPM1
NPM1: a nucleolar protein associated with nucleolar ribonucleoprotein structures and that binds single-stranded nucleic acids. Is a major component of template activating factor (TAF)-III. It plays a role in controlling centrosome duplication, and may function in the assembly and/or transport of the ribosome. Two alternatively spliced isoforms have been described.
Protein type: Nucleolus; Oncoprotein; Translation; RNA-binding
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: nucleoplasm; centrosome; focal adhesion; membrane; cytoplasm; nucleolus; spindle pole centrosome; cytosol; ribonucleoprotein complex; nucleus
Molecular Function: NF-kappaB binding; protein binding; protein homodimerization activity; protein kinase inhibitor activity; histone binding; Tat protein binding; protein heterodimerization activity; RNA binding; unfolded protein binding; transcription coactivator activity; protein kinase binding; ribosomal large subunit binding; ribosomal small subunit binding
Biological Process: regulation of centriole replication; viral reproduction; positive regulation of translation; centrosome cycle; cell aging; nucleocytoplasmic transport; signal transduction; DNA repair; protein oligomerization; activation of NF-kappaB transcription factor; nucleosome assembly; negative regulation of cell proliferation; intracellular protein transport; protein localization; regulation of endodeoxyribonuclease activity; DNA replication-independent nucleosome assembly at centromere; ribosome assembly; response to stress; negative regulation of apoptosis
Research Articles on NPM1
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Pathways associated with anti-NPM1 antibody
Diseases associated with anti-NPM1 antibody
Disease Name |
Pubmed Publications |
Leukemia, Myeloid, Acute Antibodies |
>692 publications with NPM1 and Leukemia, Myeloid, Acute |
Chromosome Aberrations Antibodies |
>92 publications with NPM1 and Chromosome Aberrations |
Cell Transformation, Neoplastic Antibodies |
>33 publications with NPM1 and Cell Transformation, Neoplastic |
Leukemia, Promyelocytic, Acute Antibodies |
>27 publications with NPM1 and Leukemia, Promyelocytic, Acute |
Carcinoma Antibodies |
>26 publications with NPM1 and Carcinoma |
Anemia Antibodies |
>16 publications with NPM1 and Anemia |
Adenocarcinoma Antibodies |
>13 publications with NPM1 and Adenocarcinoma |
Breast Neoplasms Antibodies |
>9 publications with NPM1 and Breast Neoplasms |
Neoplasms, Experimental Antibodies |
>7 publications with NPM1 and Neoplasms, Experimental |
Neoplasm Metastasis Antibodies |
>6 publications with NPM1 and Neoplasm Metastasis |
Organs/Tissues associated with anti-NPM1 antibody
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