NP_568138.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
3'-phosphoinositide-dependent protein kinase 1
NCBI Official Synonym Symbols
3'-phosphoinositide-dependent protein kinase 1; 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1; ATPDK1; PDK1; T32M21.110; T32M21_110 [Similar Products]
NCBI Protein Information
3'-phosphoinositide-dependent protein kinase 1
UniProt Protein Name
3-phosphoinositide-dependent protein kinase 1
UniProt Entry Name
PDPK1_ARATH
NCBI Summary for PDK1
Encodes 3-phosphoinositide-dependent protein kinase that contains pleckstrin homology domain and binds 3-phosphoinositides. It activates the protein kinase AGC2-1 in a phosphatidic acid dependent manner. Phosphorylates S6K1. Interacts with PID, and transphosphorylation by PDK1 increases PID autophosphorylation.
UniProt Comments for PDK1
Function: May couple lipid signals to the activation-loop phosphorylation of several protein kinases of the so-called AGC kinase family. Interacts via its pleckstrin homology domain with phosphatidic acid, PtdIns3P and PtdIns(3,4)P2 and to a lesser extent with PtdIns(4,5)P2 and PtdIns4P. May play a general role in signaling processes controlling the pathogen/stress response, polar auxin transport and development. Transphosphorylates the AGC protein kinases OXI1/AGC2-1, PK1/S6K1, PK19/S6K2 and PID resulting in their activation. Ref.1 Ref.7 Ref.9 Ref.11 Ref.12
Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Ref.6
Enzyme regulation: Activated by phosphatidic acid (PA) and in response to the fungal elicitor xylanase. Ref.10
Subunit structure: Interacts with the C-terminal PIF domain of the protein kinases D6PK/AGC1-1, OXI1/AGC2-1 and PID. Ref.7 Ref.11
Subcellular location: Cytoplasm
By similarity. Membrane; Peripheral membrane protein
By similarity. Note: Membrane-associated after cell stimulation
Tissue specificity: Ubiquitous. Ref.7
Domain: The PH domain is responsible for the interaction with the 3-phosphoinositides. The activation loop within the kinase domain is the target of phosphorylation. The PIF-binding region in the kinase domain of PDK1 acts as a docking site, enabling it to interact with and enhance the phosphorylation of substrates containing the PIF motif.
Post-translational modification: Phosphorylation on Thr-211 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Thr-211, leading to its own activation.
Sequence similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily.Contains 1 PH domain.Contains 1 protein kinase domain.
Sequence caution: The sequence CAB85557.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
Research Articles on PDK1
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Pathways associated with anti-PDK1 antibody
Organs/Tissues associated with anti-PDK1 antibody
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