View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List Mouse Plasminogen Activator Inhibitor Type 1, inhibitory Monoclonal Antibody Catalog # MBS632788 Unit / Price 0.1 mg / $805 +1 FREE 8GB USB 5x0.1 mg / $3,455 +4 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Plasminogen Activator Inhibitor Type 1, inhibitory, Monoclonal Antibody Full Product Name Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1) Product Synonym Names Anti -Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Clonality Monoclonal Isotype IgG1 Clone Number 9G249 Host Mouse Species Reactivity Human, Mouse, Rat Specificity Recognizes human plasminogen activator type-1. Species crossreactivity: mouse, rat Purity/Purification Affinity PurifiedPurified Form/Format Supplied as a liquid in PBS, 0.1% BSA. Immunogen Human PAI-1. Preparation and Storage May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Other Notes Small volumes of anti-Plasminogen Activator Inhibitor Type 1, inhibitory antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-Plasminogen Activator Inhibitor Type 1, inhibitory antibody Plasminogen activator inhibitor type-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily is an important protein in the regulation of fibrinolysis. PAI-1 is unique among the serpins because of its functional and conformational flexibility. PAI-1 is the most important physiological inhibitor of both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). Increased PAI-1 levels are associated with thrombotic events and is an established risk factor for cardiovascular diseases. The active conformation PAI-1 inhibits its target proteinases by the formation of a stable, inactive complex. Although PAI-1 is synthesized as an active molecule, it converts spontaneously to an inactive, latent form that can be partially reactivated by denaturing agents. In addition, a third conformation reacting as a non-inhibitory substrate towards various target proteinases has been identified. The epitope of monoclonal antibody MA-55F4C12 is within the stretch of 29 amino acids in PAI-1 (region Glu128-Ala131). Glu128, Val129, Glu130, Arg131 and Lys154 are the major determinants. All five residues act cooperatively in the binding to MA-55F4C12 and constitute the epitope. The epitope of the antibody does not cover the complete alpha-helix F and turn connecting alpha-helix F and beta-strand s3A, but is restricted to the hinge region between alpha-helix F and the main part of the PAI-1 molecule. The monoclonal antibody is a 'switching' antibody, capable of inducing a non-inhibitory substrate form of PAI-1. Product Categories/Family for anti-Plasminogen Activator Inhibitor Type 1, inhibitory antibody Antibodies; Abs to Coagulation Factors Application Notes for anti-Plasminogen Activator Inhibitor Type 1, inhibitory antibody Suitable for use in Immunoassays. Also useful for inhibition of biological activity. TOP NCBI/Uniprot data below describe general gene information for Plasminogen Activator Inhibitor Type 1, inhibitory. It may not necessarily be applicable to this product. NCBI GI # 189580 TOP NCBI Official Full Name plasminogen activator inhibitor type 1 TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-Plasminogen Activator Inhibitor Type 1, inhibitory antibody Reference Product PubMed Publications FLNA antibody >12 publications with Plasminogen Activator Inhibitor Type 1, inhibitory and FLNA Pathways associated with anti-Plasminogen Activator Inhibitor Type 1, inhibitory antibody Products by Pathway Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram Salmonella Infection Pathway antibodies Salmonella Infection Pathway Diagram Salmonella Infection Pathway antibodies Salmonella Infection Pathway Diagram Organs/Tissues associated with anti-Plasminogen Activator Inhibitor Type 1, inhibitory antibody Organ/Tissue Name Pubmed Publications Bone Antibodies >13 publications with Plasminogen Activator Inhibitor Type 1, inhibitory and Bone Connective Tissue Antibodies >4 publications with Plasminogen Activator Inhibitor Type 1, inhibitory and Connective Tissue Heart Antibodies >3 publications with Plasminogen Activator Inhibitor Type 1, inhibitory and Heart Muscle Antibodies >3 publications with Plasminogen Activator Inhibitor Type 1, inhibitory and Muscle Brain Antibodies >3 publications with Plasminogen Activator Inhibitor Type 1, inhibitory and Brain Vascular Antibodies >2 publications with Plasminogen Activator Inhibitor Type 1, inhibitory and Vascular Embryonic Tissue Antibodies >2 publications with Plasminogen Activator Inhibitor Type 1, inhibitory and Embryonic Tissue Ear Antibodies >1 publications with Plasminogen Activator Inhibitor Type 1, inhibitory and Ear Kidney Antibodies >1 publications with Plasminogen Activator Inhibitor Type 1, inhibitory and Kidney Umbilical Cord Antibodies >1 publications with Plasminogen Activator Inhibitor Type 1, inhibitory and Umbilical Cord TOP