AAC52113.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
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NCBI Official Full Name
post-synaptic density protein 95
NCBI Official Synonym Full Names
discs, large homolog 4 (Drosophila)
NCBI Protein Information
disks large homolog 4; discs large homolog 4; Tax interaction protein 15; synapse-associated protein 90; postsynaptic density protein 95; post-synaptic density protein 95
UniProt Protein Name
Disks large homolog 4
UniProt Synonym Protein Names
Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90
UniProt Synonym Gene Names
UniProt Entry Name
DLG4_HUMAN
NCBI Summary for DLG4
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for DLG4
PSD-95: a membrane associated guanylate kinase (MAGUK) scaffolding protein located in neural postsynaptic densities. Associates with NMDA receptor NR2 subunits via glutamate serine (aspartate/glutamate) valine motifs in the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Its overexpression or depletion changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. Binds tissue-type plasminogen activator (tPA), mediating neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. Interacts through its first two PDZ domains with NMDAR2A, NMDAR2B, NMDAR2C, NMDAR2D, ACCN3, certain splice forms of NMDAR1, KV4.2, CXADR and synGAP. Interacts through its first two PDZ domains with Kv1.1, Kv1.2, Kv1.3, Kv1.4 and HER4. Interacts through its first PDZ domain with GluR6 and Kv1.4. Interacts through its second PDZ domain with the PDZ domain of nNOS or the C-terminus of NOS1AP. May interact with 5-HT(2A). Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with SAPAP1, SAPAP2, SAPAP3, SAPAP4, MAP1A, and BEGAIN. Interacts through its guanylate kinase-like domain with KIF13B. Two alternatively spliced human isoforms have been reported. Palmitoylation of isoform 1 is required for targeting to postsynaptic density.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: dendrite cytoplasm; cortical cytoskeleton; voltage-gated potassium channel complex; basolateral plasma membrane; endoplasmic reticulum; postsynaptic density; dendritic spine; excitatory synapse; postsynaptic membrane; synaptic vesicle; extrinsic to internal side of plasma membrane; cytoplasm; plasma membrane; ionotropic glutamate receptor complex; synapse; cell junction
Molecular Function: protein C-terminus binding; P2Y1 nucleotide receptor binding; ionotropic glutamate receptor binding; guanylate kinase activity; protein binding; beta-1 adrenergic receptor binding; protein complex binding; acetylcholine receptor binding; D1 dopamine receptor binding; protein phosphatase binding; PDZ domain binding
Biological Process: regulation of long-term neuronal synaptic plasticity; nervous system development; axon guidance; synaptic vesicle maturation; learning; social behavior; signal transduction; positive regulation of synaptic transmission; establishment and/or maintenance of epithelial cell polarity; synaptic transmission; establishment of protein localization; elevation of cytosolic calcium ion concentration; protein complex assembly; neuromuscular process controlling balance; negative regulation of receptor internalization; nucleotide phosphorylation
Research Articles on DLG4
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Products associated with anti-DLG4 antibody
Pathways associated with anti-DLG4 antibody
Diseases associated with anti-DLG4 antibody
Organs/Tissues associated with anti-DLG4 antibody
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