NP_055113
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,846 Da
NCBI Official Full Name
nicotinate-nucleotide pyrophosphorylase
NCBI Official Synonym Full Names
quinolinate phosphoribosyltransferase
NCBI Protein Information
nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt Protein Name
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt Synonym Protein Names
Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase
UniProt Synonym Gene Names
UniProt Entry Name
NADC_HUMAN
NCBI Summary for QPRT
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq, Jul 2008]
UniProt Comments for QPRT
QPRT: Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
Protein type: Transferase; EC 2.4.2.19; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cytoplasm; cytosol
Molecular Function: protein homodimerization activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity
Biological Process: NAD biosynthetic process; vitamin metabolic process; NAD metabolic process; protein oligomerization; water-soluble vitamin metabolic process
Research Articles on QPRT
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Pathways associated with anti-QPRT antibody
Diseases associated with anti-QPRT antibody
Organs/Tissues associated with anti-QPRT antibody
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