NP_689969.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
195,011 Da
NCBI Official Full Name
rapamycin-insensitive companion of mTOR isoform 1
NCBI Official Synonym Full Names
RPTOR independent companion of MTOR, complex 2
NCBI Protein Information
rapamycin-insensitive companion of mTOR
UniProt Protein Name
Rapamycin-insensitive companion of mTOR
UniProt Synonym Protein Names
AVO3 homolog; hAVO3
UniProt Synonym Gene Names
UniProt Entry Name
RICTR_HUMAN
NCBI Summary for RICTOR
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
UniProt Comments for RICTOR
RICTOR: a regulatory binding partner of the kinase mTOR. Part of a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Rictor interacts with Cullin1-Rbx1 to form an E3 ubiquitin ligase complex, and promotes ubiquitination and degradation of SGK1. Shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae.
Protein type: Adaptor/scaffold; Ubiquitin conjugating system; Cell cycle regulation
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component: TORC2 complex; cytosol
Molecular Function: protein binding; ribosome binding; protein kinase binding
Biological Process: epidermal growth factor receptor signaling pathway; TOR signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; regulation of protein kinase B signaling cascade; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; embryonic development; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; actin cytoskeleton reorganization; T cell costimulation; innate immune response; positive regulation of endothelial cell proliferation; vascular endothelial growth factor receptor signaling pathway; positive regulation of TOR signaling pathway
Research Articles on RICTOR
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Products associated with anti-RICTOR antibody
Pathways associated with anti-RICTOR antibody
Diseases associated with anti-RICTOR antibody
Organs/Tissues associated with anti-RICTOR antibody
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