NP_005622.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
86,397 Da
NCBI Official Full Name
smoothened homolog
NCBI Official Synonym Full Names
smoothened, frizzled class receptor
NCBI Protein Information
smoothened homolog; protein Gx; frizzled family member 11; seven transmembrane helix receptor; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor
UniProt Protein Name
Smoothened homolog
UniProt Synonym Protein Names
Protein Gx
UniProt Synonym Gene Names
UniProt Entry Name
SMO_HUMAN
NCBI Summary for SMO
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]
UniProt Comments for SMO
SMO: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. Belongs to the G-protein coupled receptor Fz/Smo family.
Protein type: Oncoprotein; GPCR, Fz/Smo family; Cell development/differentiation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 7q32.3
Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; integral to membrane; plasma membrane; caveola
Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity; protein binding; patched binding; drug binding
Biological Process: developmental growth; central nervous system neuron differentiation; ventral midline determination; negative regulation of epithelial cell differentiation; skeletal muscle fiber development; cell fate specification; thalamus development; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; anterior/posterior pattern formation; positive regulation of mesenchymal cell proliferation; positive regulation of smoothened signaling pathway; heart looping; vasculogenesis; neural crest cell migration; activation of hh target transcription factor; dorsoventral neural tube patterning; positive regulation of neuroblast proliferation; smoothened signaling pathway; hair follicle morphogenesis; protein stabilization; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; in utero embryonic development; multicellular organism growth; smoothened signaling pathway in ventral spinal cord patterning; forebrain morphogenesis; negative regulation of hair follicle development; negative regulation of DNA binding; odontogenesis of dentine-containing teeth; osteoblast differentiation; G-protein coupled receptor protein signaling pathway; cerebellar cortex morphogenesis; positive regulation of protein import into nucleus; myoblast migration; midgut development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of epithelial cell proliferation; negative regulation of apoptosis
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Products associated with anti-SMO antibody
Pathways associated with anti-SMO antibody
Diseases associated with anti-SMO antibody
Disease Name |
Pubmed Publications |
Carcinoma, Basal Cell Antibodies |
>138 publications with SMO and Carcinoma, Basal Cell |
Nervous System Diseases Antibodies |
>89 publications with SMO and Nervous System Diseases |
Skin Neoplasms Antibodies |
>65 publications with SMO and Skin Neoplasms |
Neuroectodermal Tumors, Primitive Antibodies |
>59 publications with SMO and Neuroectodermal Tumors, Primitive |
Disease Models, Animal Antibodies |
>54 publications with SMO and Disease Models, Animal |
Brain Neoplasms Antibodies |
>46 publications with SMO and Brain Neoplasms |
Neoplasms, Experimental Antibodies |
>28 publications with SMO and Neoplasms, Experimental |
Neoplasm Metastasis Antibodies |
>26 publications with SMO and Neoplasm Metastasis |
Genital Diseases, Male Antibodies |
>21 publications with SMO and Genital Diseases, Male |
Liver Diseases Antibodies |
>20 publications with SMO and Liver Diseases |
Organs/Tissues associated with anti-SMO antibody
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