P07477.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,558 Da
NCBI Official Full Name
Trypsin-1
NCBI Official Synonym Full Names
protease, serine, 1 (trypsin 1)
NCBI Protein Information
trypsin-1; beta-trypsin; trypsinogen 1; trypsinogen A; digestive zymogen; cationic trypsinogen; nonfunctional trypsin 1
UniProt Protein Name
Trypsin-1
UniProt Synonym Protein Names
Beta-trypsin; Cationic trypsinogen; Serine protease 1; Trypsin I
UniProt Synonym Gene Names
UniProt Entry Name
TRY1_HUMAN
NCBI Summary for TRYPSIN
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]
UniProt Comments for TRYPSIN
Function: Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates. Ref.9
Catalytic activity: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
Cofactor: Binds 1 calcium ion per subunit.
Subcellular location: Secreted › extracellular space.
Post-translational modification: Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122.
Involvement in disease: Pancreatitis (PCTT) [MIM:167800]: A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8 Ref.11 Ref.12 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23
Sequence similarities: Belongs to the peptidase S1 family.Contains 1 peptidase S1 domain.
Caution: Tyr-154 was proposed to be phosphorylated (Ref.15) but it has been shown (Ref.14) to be sulfated instead. Phosphate and sulfate groups are similar in mass and size, and this can lead to erroneous interpretation of the results.
Mass spectrometry: Molecular mass is 24348±2 Da from positions 24 - 247. Determined by ESI. Ref.15
Research Articles on TRYPSIN
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Pathways associated with anti-TRYPSIN antibody
Diseases associated with anti-TRYPSIN antibody
Organs/Tissues associated with anti-TRYPSIN antibody
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