NP_821133.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,671 Da
NCBI Official Full Name
tubulin beta chain isoform b
NCBI Official Synonym Full Names
tubulin, beta class I
NCBI Official Synonym Symbols
M40; TUBB1; TUBB5; CDCBM6; OK/SW-cl.56 [Similar Products]
NCBI Protein Information
tubulin beta chain; beta Ib tubulin; tubulin beta-1 chain; tubulin beta-5 chain; tubulin, beta polypeptide
UniProt Protein Name
Tubulin beta chain
UniProt Synonym Protein Names
Tubulin beta-5 chain
UniProt Synonym Gene Names
UniProt Entry Name
TBB5_HUMAN
NCBI Summary for TUBB
This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]
UniProt Comments for TUBB
TUBB: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. May interact with RNABP10. Interacts with PIFO/C1orf88. Ubiquitously expressed with highest levels in spleen, thymus and immature brain. Belongs to the tubulin family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6p21.33
Cellular Component: microtubule; cytoskeleton; nuclear envelope lumen; nucleus; cytosol
Molecular Function: GTPase activity; protein domain specific binding; protein binding; GTP binding; structural constituent of cytoskeleton; MHC class I protein binding; ubiquitin protein ligase binding; protein complex binding; GTPase activating protein binding; structural molecule activity
Biological Process: protein polymerization; metabolic process; natural killer cell mediated cytotoxicity; cell division; organelle organization and biogenesis; mitotic cell cycle; spindle assembly; cytoskeleton-dependent intracellular transport; G2/M transition of mitotic cell cycle; cell motility; cellular process; microtubule-based process
Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 6
Research Articles on TUBB
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Products associated with anti-TUBB antibody
Pathways associated with anti-TUBB antibody
Diseases associated with anti-TUBB antibody
Organs/Tissues associated with anti-TUBB antibody
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