NP_001292074.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,472 Da
NCBI Official Full Name
tomoregulin-2 isoform 3
NCBI Official Synonym Full Names
transmembrane protein with EGF-like and two follistatin-like domains 2
NCBI Official Synonym Symbols
TR; HPP1; TPEF; TR-2; TENB2; CT120.2 [Similar Products]
NCBI Protein Information
tomoregulin-2; cancer/testis antigen family 120, member 2; hyperplastic polyposis protein 1; transmembrane protein TENB2
UniProt Protein Name
Tomoregulin-2
UniProt Synonym Protein Names
Hyperplastic polyposis protein 1; Transmembrane protein with EGF-like and two follistatin-like domains
UniProt Synonym Gene Names
UniProt Entry Name
TEFF2_HUMAN
NCBI Summary for TMEFF2
This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
UniProt Comments for TMEFF2
TMEFF2: may be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. A member of the Cancer-Testis Antigen (CTA) superfamily. CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques. Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines. Belongs to the tomoregulin family. Three isoforms of the human protein are produced by alternative splicing. Isoform three is expressed weakly in testis and at high levels in normal and cancerous prostate. Note: This description may include information from RefSeq and UniProtKB
Protein type: Membrane protein, integral; Cancer Testis Antigen (CTA); Cell surface
Chromosomal Location of Human Ortholog: 2q32.3
Cellular Component: integral to membrane; extracellular region
Research Articles on TMEFF2
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Pathways associated with anti-TMEFF2 antibody
Diseases associated with anti-TMEFF2 antibody
Organs/Tissues associated with anti-TMEFF2 antibody
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