View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-XRCC1 antibody :: Mouse anti-Human, Rat XRCC1 Monoclonal Antibody Catalog # MBS602221 Unit / Price 0.5 mL / $995 +1 FREE 8GB USB 5x0.5 mL / $4,300 +5 FREE 8GB USB Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name XRCC1, Monoclonal Antibody Full Product Name XRCC1 (X-Ray Repair Cross Complementing Protein1) Product Synonym Names Anti -XRCC1 (X-Ray Repair Cross Complementing Protein1) Product Gene Name anti-XRCC1 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Immunogen Sequence Not determined Chromosome Location Chromosome: 19; NC_000019.9 (44047464..44079730, complement). Location: 19q13.2 OMIM 194360 3D Structure ModBase 3D Structure for P18887 Clonality Monoclonal Isotype IgG2b Clone Number 3F400 Host Mouse Species Reactivity Human, Rat Specificity Recognizes XRCC1 (X-Ray Repair Cross Complementing Protein1). Species Crossreactivity: human and rat. Purity/Purification Affinity PurifiedPurified by Protein A affinity chromatography. Form/Format Supplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide. See X9501-01X Immunogen Recombinant human XRCC1 protein Cellular Localization Nuclear Positive Control Ls174T, HT29, or HeLa cells. Normal testis. Preparation and Storage May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at-20 degree C or colder. Aliquots are stable for at least 12 months at-20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Other Notes Small volumes of anti-XRCC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-XRCC1 antibody X-Ray Repair Cross Complementing (XRCC1) plays a role in excision repair of DNA after ionizing irradiation. XRCC1 binds to DNA ligase III through the C-terminal 96 amino acids and to DNA polymerase beta through the N-terminal half.. In testis XRCC1 is expressed at high levels. Cells with a mutation of this gene exhibit decreased single strand break repair and reduced recombination repair. They show increased double strand breaks, and sister chromatid exchange is increased up to 10-fold. The XRCC1 might serve as a scaffold protein during base excision-repair. Product Categories/Family for anti-XRCC1 antibody Antibodies; Abs to Transcription Factors Applications Tested/Suitable for anti-XRCC1 antibody Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC) Application Notes for anti-XRCC1 antibody Dilution: Immunoprecipitation (Native verified) (Use Protein A) (Ab 2ug/mg protein lysate)Western Blotting (Ab 1-2ug/ml for 2hrs at RT)Immunohistochemistry (Formalin/paraffin) (1-2ug/ml for 30 min at RT; is better) * [Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.] The optimal dilution for a specific application should be determined by the investigator. Testing Data of anti-XRCC1 antibody Testing Data of anti-XRCC1 antibody Immunohistochemistry (IHC) of anti-XRCC1 antibody Formalin-fixed, paraffin-embedded rat testis stained with XRCC1 Ab using peroxidase-conjugate and AEC chromogen. Note nuclear staining of spermatocytes. Testing Data of anti-XRCC1 antibody TOP NCBI/Uniprot data below describe general gene information for XRCC1. It may not necessarily be applicable to this product. NCBI GI # 48145573 NCBI GeneID 7515 UniProt Primary Accession # P18887 [Other Products] UniProt Secondary Accession # Q6IBS4; Q9HCB1[Other Products] UniProt Related Accession # P18887; Q59HH7[Other Products] Molecular Weight 85kD[Similar Products] TOP NCBI Official Full Name XRCC1 NCBI Official Synonym Full Names X-ray repair complementing defective repair in Chinese hamster cells 1 NCBI Official Symbol XRCC1 [Similar Products] NCBI Official Synonym Symbols RCC [Similar Products] NCBI Protein Information DNA repair protein XRCC1; X-ray repair cross-complementing protein 1; X-ray-repair, complementing defective, repair in Chinese hamster UniProt Protein Name DNA repair protein XRCC1 UniProt Synonym Protein Names X-ray repair cross-complementing protein 1 Protein Family DNA repair protein UniProt Gene Name XRCC1 [Similar Products] UniProt Entry Name XRCC1_HUMAN TOP NCBI Summary for XRCC1 The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq] TOP UniProt Comments for XRCC1 XRCC1: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.Protein type: DNA repair, damageChromosomal Location of Human Ortholog: 19q13.2Cellular Component: nucleoplasm; nucleusMolecular Function: protein binding; enzyme binding; damaged DNA bindingBiological Process: single strand break repair; base-excision repair; DNA repair Research Articles on XRCC1 1. XRCC1 codon 399 Gln/Gln genotype is associated with reduced susceptibility to CpG island hyper methylation especially DAP-kinase. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-XRCC1 antibody Reference Product PubMed Publications OGG1 antibody >71 publications with XRCC1 and OGG1 APEX1 antibody >70 publications with XRCC1 and APEX1 PARP1 antibody >39 publications with XRCC1 and PARP1 Pathways associated with anti-XRCC1 antibody Products by Pathway Pathway Diagram Base Excision Repair Pathway antibodies Base Excision Repair Pathway Diagram Base Excision Repair Pathway antibodies Base Excision Repair Pathway Diagram Base Excision Repair Pathway antibodies Base Excision Repair Pathway Diagram DNA Repair Pathway antibodies DNA Repair Pathway Diagram E2F Transcription Factor Network Pathway antibodies E2F Transcription Factor Network Pathway Diagram FOXM1 Transcription Factor Network Pathway antibodies FOXM1 Transcription Factor Network Pathway Diagram Resolution Of AP Sites Via The Single-nucleotide Replacement Pathway antibodies Resolution Of AP Sites Via The Single-nucleotide Replacement Pathway Diagram Resolution Of Abasic Sites (AP Sites) Pathway antibodies Resolution Of Abasic Sites (AP Sites) Pathway Diagram Diseases associated with anti-XRCC1 antibody Disease Name Pubmed Publications Neoplasms Antibodies >510 publications with XRCC1 and Neoplasms Carcinoma Antibodies >189 publications with XRCC1 and Carcinoma Gastrointestinal Neoplasms Antibodies >110 publications with XRCC1 and Gastrointestinal Neoplasms Lung Neoplasms Antibodies >99 publications with XRCC1 and Lung Neoplasms Lung Diseases Antibodies >98 publications with XRCC1 and Lung Diseases Skin Diseases Antibodies >91 publications with XRCC1 and Skin Diseases Breast Neoplasms Antibodies >84 publications with XRCC1 and Breast Neoplasms Urogenital Neoplasms Antibodies >78 publications with XRCC1 and Urogenital Neoplasms Head and Neck Neoplasms Antibodies >76 publications with XRCC1 and Head and Neck Neoplasms Adenocarcinoma Antibodies >75 publications with XRCC1 and Adenocarcinoma Organs/Tissues associated with anti-XRCC1 antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >171 publications with XRCC1 and Blood Lung Antibodies >126 publications with XRCC1 and Lung Bladder Antibodies >41 publications with XRCC1 and Bladder Prostate Antibodies >30 publications with XRCC1 and Prostate Ovary Antibodies >28 publications with XRCC1 and Ovary Brain Antibodies >27 publications with XRCC1 and Brain Liver Antibodies >24 publications with XRCC1 and Liver Skin Antibodies >22 publications with XRCC1 and Skin Thyroid Antibodies >10 publications with XRCC1 and Thyroid Bone Antibodies >10 publications with XRCC1 and Bone TOP © 2006-24 MyBioSource.com. 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