BC001060
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,044 Da
NCBI Official Full Name
Homo sapiens paired box 8, mRNA
NCBI Official Synonym Full Names
paired box 8
NCBI Protein Information
paired box protein Pax-8; paired domain gene 8
UniProt Protein Name
Paired box protein Pax-8
UniProt Entry Name
PAX8_HUMAN
NCBI Summary for PAX8
This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
UniProt Comments for PAX8
PAX8: Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Interacts with WWTR1. Expressed in the excretory system, thyroid gland and Wilms tumors. 5 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 2q13
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; DNA binding; transcription factor activity; thyroid-stimulating hormone receptor activity
Biological Process: regulation of apoptosis; inner ear morphogenesis; anatomical structure morphogenesis; central nervous system development; transcription, DNA-dependent; ureteric bud branching; positive regulation of transcription, DNA-dependent; thyroid gland development; mesonephros development; positive regulation of transcription from RNA polymerase II promoter; kidney development; pronephros development; urogenital system development
Disease: Hypothyroidism, Congenital, Nongoitrous, 2
Research Articles on PAX8
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Products associated with anti-PAX8 antibody
Pathways associated with anti-PAX8 antibody
Diseases associated with anti-PAX8 antibody
Organs/Tissues associated with anti-PAX8 antibody
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