NP_061985.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
218,497 Da
NCBI Official Full Name
ATP-binding cassette sub-family A member 7
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family A (ABC1), member 7
NCBI Protein Information
ATP-binding cassette sub-family A member 7; autoantigen SS-N; macrophage ABC transporter
UniProt Protein Name
ATP-binding cassette sub-family A member 7
UniProt Synonym Protein Names
ABCA-SSN; Autoantigen SS-N; Macrophage ABC transporter
UniProt Entry Name
ABCA7_HUMAN
NCBI Summary for ABCA7
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCA7
ABCA7: Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. Belongs to the ABC transporter superfamily. ABCA family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral; Transporter, ABC family
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: Golgi membrane; Golgi apparatus; cell surface; cytoplasm; apical plasma membrane; plasma membrane; integral to membrane; endosome membrane; ATP-binding cassette (ABC) transporter complex; phagocytic cup
Molecular Function: apolipoprotein A-I receptor activity; phospholipid transporter activity; transporter activity; ATPase activity; ATP binding
Biological Process: phospholipid efflux; positive regulation of ATPase activity; negative regulation of amyloid precursor protein biosynthetic process; positive regulation of phagocytosis; cholesterol efflux; peptide cross-linking; phospholipid scrambling; negative regulation of ATPase activity; transmembrane transport; phagocytosis; memory
Research Articles on ABCA7
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Products associated with anti-ABCA7 antibody
Pathways associated with anti-ABCA7 antibody
Diseases associated with anti-ABCA7 antibody
Organs/Tissues associated with anti-ABCA7 antibody
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