AAH20618.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ABCB4 protein
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family B (MDR/TAP), member 4
NCBI Official Synonym Symbols
GBD1; ICP3; MDR2; MDR3; PGY3; ABC21; MDR2/3; PFIC-3 [Similar Products]
NCBI Protein Information
multidrug resistance protein 3; P-glycoprotein 3; multiple drug resistance 3; ATP-binding cassette sub-family B member 4; P glycoprotein 3/multiple drug resistance 3; P-glycoprotein-3/multiple drug resistance-3
UniProt Protein Name
Multidrug resistance protein 3
UniProt Synonym Protein Names
ATP-binding cassette sub-family B member 4; P-glycoprotein 3
UniProt Synonym Gene Names
UniProt Entry Name
MDR3_HUMAN
NCBI Summary for ABCB4
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCB4
Function: Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.
Catalytic activity: ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
Subunit structure: Interacts with HAX1
By similarity.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Involvement in disease: Cholestasis, progressive familial intrahepatic, 3 (PFIC3) [MIM:602347]: A disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.11 Ref.13Cholestasis of pregnancy, intrahepatic 3 (ICP3) [MIM:614972]: A liver disorder of pregnancy. It presents during the second or, more commonly, the third trimester of pregnancy with intense pruritus which becomes more severe with advancing gestation and cholestasis. It causes fetal distress, spontaneous premature delivery and intrauterine death. Patients have spontaneous and progressive disappearance of cholestasis after delivery. Cholestasis results from abnormal biliary transport from the liver into the small intestine.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.15 Ref.16Gallbladder disease 1 (GBD1) [MIM:600803]: One of the major digestive diseases. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations in western countries. Most people with gallstones, however, remain asymptomatic through their lifetimes.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12 Ref.14
Sequence similarities: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Contains 2 ABC transmembrane type-1 domains.Contains 2 ABC transporter domains.
Sequence caution: The sequence CAA84542.1 differs from that shown. Reason: Probable cloning artifact.
Research Articles on ABCB4
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Products associated with anti-ABCB4 antibody
Pathways associated with anti-ABCB4 antibody
Diseases associated with anti-ABCB4 antibody
Organs/Tissues associated with anti-ABCB4 antibody
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