NP_000672.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
alpha-2A adrenergic receptor
NCBI Official Synonym Full Names
adrenergic, alpha-2A-, receptor
NCBI Official Synonym Symbols
ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR [Similar Products]
NCBI Protein Information
alpha-2A adrenergic receptor; OTTHUMP00000020485; alpha-2A adrenoceptor; alpha-2AAR subtype C10; alpha-2A adrenoreceptor; alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type
UniProt Protein Name
Alpha-2A adrenergic receptor
UniProt Synonym Protein Names
Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor
UniProt Synonym Gene Names
UniProt Entry Name
ADA2A_HUMAN
NCBI Summary for ADRA2A
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq]
UniProt Comments for ADRA2A
ADRA2A: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 10q25.2
Cellular Component: integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane; synapse; receptor complex
Molecular Function: protein binding; protein homodimerization activity; alpha-2C adrenergic receptor binding; protein heterodimerization activity; thioesterase binding; alpha2-adrenergic receptor activity; alpha-1B adrenergic receptor binding; norepinephrine binding; epinephrine binding; protein kinase binding; heterotrimeric G-protein binding
Biological Process: fear response; negative regulation of calcium ion-dependent exocytosis; positive regulation of potassium ion transport; female pregnancy; thermoception; positive regulation of vasodilation; signal transduction; glucose homeostasis; positive regulation of membrane protein ectodomain proteolysis; Rho protein signal transduction; intestinal absorption; negative regulation of insulin secretion; positive regulation of MAP kinase activity; negative regulation of cAMP biosynthetic process; positive regulation of epidermal growth factor receptor activity; negative regulation of lipid catabolic process; positive regulation of cell proliferation; DNA replication; positive regulation of cytokine production; platelet activation; negative regulation of calcium ion transport; activation of protein kinase B; negative regulation of adenylate cyclase activity; cellular response to hormone stimulus; G-protein coupled receptor protein signaling pathway; regulation of vasoconstriction; Ras protein signal transduction; activation of protein kinase activity; energy reserve metabolic process; negative regulation of epinephrine secretion; cell motility; actin cytoskeleton organization and biogenesis; blood coagulation; regulation of insulin secretion; acute inflammatory response; positive regulation of cell migration
Research Articles on ADRA2A
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Products associated with anti-ADRA2A antibody
Pathways associated with anti-ADRA2A antibody
Diseases associated with anti-ADRA2A antibody
Organs/Tissues associated with anti-ADRA2A antibody
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