View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-FOXO4 antibody :: Rabbit anti-Human AFX Polyclonal Antibody Catalog # MBS621025 Unit / Price 0.1 mg / $535 +1 FREE 8GB USB 5x0.1 mg / $2,235 +2 FREE 8GB USB Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name AFX (FOXO4), Polyclonal Antibody Full Product Name AFX Product Synonym Names Anti -AFX Product Gene Name anti-FOXO4 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Chromosome Location Chromosome: X; NC_000023.10 (70315999..70323384). Location: Xq13.1 OMIM 300033 3D Structure ModBase 3D Structure for P98177 Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human Specificity Detects endogenous levels of total AFX protein. Purity/Purification Affinity PurifiedPurified by immunoaffinity chromatography. Form/Format Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide and 50% glycerol. Immunogen Synthesized non-phosphopeptide derived from human AFX around the phosphorylation site of serine 197 Preparation and Storage For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Other Notes Small volumes of anti-FOXO4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-FOXO4 antibody Several studies indicate that FKHR and AFX, mammalian homologues of the Caenorhabditis elegans forkhead transcription factor DAF-16, function in the insulin signaling pathway promoter contains one IRS, while in the IGFBP-1 promoter two copies of IRS are arranged as an inverted palindrome. Three tandem copies of IRSs are present in the G6Pase. AFX has been recently shown to serve as a substrate of PKB both in vitro and in vivo, and its transcriptional activity is inhibited by phosphorylation. Product Categories/Family for anti-FOXO4 antibody Antibodies; Abs to Transcription Factors Applications Tested/Suitable for anti-FOXO4 antibody Western Blot (WB), Immunohistochemistry (IHC) Application Notes for anti-FOXO4 antibody Suitable for use in Western Blot and Immunohistochemistry.Dilution: Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:100 Immunohistochemistry (IHC) of anti-FOXO4 antibody Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using rabbit anti-AFX. Western Blot (WB) of anti-FOXO4 antibody Western Blot analysis of extracts from 293 cells using ATX antibody (Line 1 & 2) and ATX (phospho-Ser197) antibody (Line 3 & 4). TOP NCBI/Uniprot data below describe general gene information for FOXO4. It may not necessarily be applicable to this product. NCBI GI # 1418759 NCBI GeneID 4303 UniProt Primary Accession # P98177 [Other Products] UniProt Secondary Accession # O43821; Q13720; Q3KPF1; Q8TDK9; B7WPJ7[Other Products] UniProt Related Accession # P98177[Other Products] Molecular Weight 53,684 Da[Similar Products] TOP NCBI Official Full Name AFX NCBI Official Synonym Full Names forkhead box O4 NCBI Official Symbol FOXO4 [Similar Products] NCBI Official Synonym Symbols AFX; AFX1; MLLT7; MGC120490 [Similar Products] NCBI Protein Information forkhead box protein O4; OTTHUMP00000023496; OTTHUMP00000023497; fork head domain transcription factor AFX1; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 UniProt Protein Name Forkhead box protein O4 UniProt Synonym Protein Names Fork head domain transcription factor AFX1 Protein Family Forkhead box protein UniProt Gene Name FOXO4 [Similar Products] UniProt Synonym Gene Names AFX; AFX1; MLLT7 [Similar Products] UniProt Entry Name FOXO4_HUMAN TOP NCBI Summary for FOXO4 This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] TOP UniProt Comments for FOXO4 FOXO4: transcription factor AFX1 containing 1 fork-head domain. May play a role in the insulin signaling pathway. Involved in acute leukemias by a chromosomal translocation t(X;11)(q13;q23) that involves MLLT7 and MLL/HRX. The result is a rogue activator protein. Two splice-variant isoforms have been described.Protein type: Oncoprotein; Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: Xq13.1Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosolMolecular Function: protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; transcription factor activity; transcription factor bindingBiological Process: transcription from RNA polymerase II promoter; epidermal growth factor receptor signaling pathway; muscle development; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; negative regulation of smooth muscle cell differentiation; stem cell differentiation; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; negative regulation of angiogenesis; regulation of transcription, DNA-dependent; mitotic cell cycle G2/M transition DNA damage checkpoint; insulin receptor signaling pathway; innate immune response; cell cycle arrest Research Articles on FOXO4 1. greater in fetal membranes obtained from the supracervical compared to distal site TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-FOXO4 antibody Reference Product PubMed Publications AKT1 antibody >15 publications with FOXO4 and AKT1 CCND1 antibody >8 publications with FOXO4 and CCND1 CTNNB1 antibody >4 publications with FOXO4 and CTNNB1 CREBBP antibody >3 publications with FOXO4 and CREBBP AKT2 antibody >1 publications with FOXO4 and AKT2 SMAD4 antibody >1 publications with FOXO4 and SMAD4 FOXG1 antibody >1 publications with FOXO4 and FOXG1 Pathways associated with anti-FOXO4 antibody Products by Pathway Pathway Diagram AKT Phosphorylates Targets In The Nucleus Pathway antibodies AKT Phosphorylates Targets In The Nucleus Pathway Diagram Class I PI3K Signaling Events Mediated By Akt Pathway antibodies Class I PI3K Signaling Events Mediated By Akt Pathway Diagram Downstream Signaling Of Activated FGFR Pathway antibodies Downstream Signaling Of Activated FGFR Pathway Diagram FoxO Family Signaling Pathway antibodies FoxO Family Signaling Pathway Diagram IL-6 Signaling Pathway antibodies IL-6 Signaling Pathway Diagram NGF Signalling Via TRKA From The Plasma Membrane Pathway antibodies NGF Signalling Via TRKA From The Plasma Membrane Pathway Diagram PI-3K Cascade Pathway antibodies PI-3K Cascade Pathway Diagram PI3K/AKT Activation Pathway antibodies PI3K/AKT Activation Pathway Diagram PIP3 Activates AKT Signaling Pathway antibodies PIP3 Activates AKT Signaling Pathway Diagram Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram Diseases associated with anti-FOXO4 antibody Disease Name Pubmed Publications Neoplasms Antibodies >31 publications with FOXO4 and Neoplasms Cardiovascular Diseases Antibodies >9 publications with FOXO4 and Cardiovascular Diseases Ischemia Antibodies >7 publications with FOXO4 and Ischemia Inflammation Antibodies >6 publications with FOXO4 and Inflammation Metabolic Diseases Antibodies >6 publications with FOXO4 and Metabolic Diseases Colorectal Neoplasms Antibodies >4 publications with FOXO4 and Colorectal Neoplasms Diabetes Mellitus Antibodies >4 publications with FOXO4 and Diabetes Mellitus Lung Neoplasms Antibodies >3 publications with FOXO4 and Lung Neoplasms Breast Neoplasms Antibodies >3 publications with FOXO4 and Breast Neoplasms Colonic Neoplasms Antibodies >3 publications with FOXO4 and Colonic Neoplasms Organs/Tissues associated with anti-FOXO4 antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >29 publications with FOXO4 and Blood Liver Antibodies >11 publications with FOXO4 and Liver Brain Antibodies >9 publications with FOXO4 and Brain Embryonic Tissue Antibodies >8 publications with FOXO4 and Embryonic Tissue Ovary Antibodies >6 publications with FOXO4 and Ovary Kidney Antibodies >5 publications with FOXO4 and Kidney Bone Antibodies >5 publications with FOXO4 and Bone Prostate Antibodies >3 publications with FOXO4 and Prostate Intestine Antibodies >3 publications with FOXO4 and Intestine Eye Antibodies >3 publications with FOXO4 and Eye TOP © 2006-24 MyBioSource.com. 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