NP_003213.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,010 Da
NCBI Official Full Name
transcription factor AP-2 gamma
NCBI Official Synonym Full Names
transcription factor AP-2 gamma
NCBI Official Synonym Symbols
ERF1; TFAP2G; hAP-2g; AP2-GAMMA [Similar Products]
NCBI Protein Information
transcription factor AP-2 gamma
UniProt Protein Name
Transcription factor AP-2 gamma
UniProt Synonym Protein Names
Activating enhancer-binding protein 2 gamma; Transcription factor ERF-1
UniProt Synonym Gene Names
UniProt Entry Name
AP2C_HUMAN
NCBI Summary for TFAP2C
The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]
UniProt Comments for TFAP2C
AP-2 gamma: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. During retinoic acid-mediated differentiation. Belongs to the AP-2 family.
Protein type: Motility/polarity/chemotaxis; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 20q13.2
Cellular Component: mitochondrion; nucleoplasm; nucleus
Molecular Function: DNA binding; protein binding; protein dimerization activity; transcription factor activity
Biological Process: cell-cell signaling; male gonad development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of gene expression, epigenetic; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Research Articles on TFAP2C
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Products associated with anti-TFAP2C antibody
Diseases associated with anti-TFAP2C antibody
Organs/Tissues associated with anti-TFAP2C antibody
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