NP_004307.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
achaete-scute homolog 1
NCBI Official Synonym Full Names
achaete-scute complex homolog 1 (Drosophila)
NCBI Protein Information
achaete-scute homolog 1; ASH-1; achaete scute protein; achaete-scute complex-like 1; class A basic helix-loop-helix protein 46
UniProt Protein Name
Achaete-scute homolog 1
UniProt Synonym Protein Names
Class A basic helix-loop-helix protein 46
UniProt Synonym Gene Names
UniProt Entry Name
ASCL1_HUMAN
NCBI Summary for ASCL1
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq]
UniProt Comments for ASCL1
ASCL1: Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5'-CANNTG-3').
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12q23.2
Cellular Component: cell soma; nucleus
Molecular Function: protein binding; protein homodimerization activity; DNA binding; double-stranded DNA binding; bHLH transcription factor binding; chromatin binding; transcription factor activity
Biological Process: vestibular nucleus development; response to lithium ion; musculoskeletal movement, spinal reflex action; olfactory pit development; regulation of mitotic cell cycle; cell maturation; neuron migration; neuroblast fate determination; negative regulation of transcription from RNA polymerase II promoter; sympathetic nervous system development; positive regulation of neuron apoptosis; response to folic acid; neuron fate specification; oligodendrocyte development; positive regulation of Notch signaling pathway; central nervous system neuron development; Notch signaling pathway; response to retinoic acid; transcription, DNA-dependent; spinal cord oligodendrocyte cell fate specification; regulation of timing of subpallium neuron differentiation; positive regulation of cell cycle; cerebral cortex GABAergic interneuron differentiation; negative regulation of neuron differentiation; neurogenesis; subpallium neuron fate commitment; commitment of a neuronal cell to a specific type of neuron in the forebrain; regulation of gene expression; neuroblast proliferation; regulation of epithelial cell differentiation; spinal cord association neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; positive regulation of neuron differentiation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
Disease: Central Hypoventilation Syndrome, Congenital
Research Articles on ASCL1
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Products associated with anti-ASCL1 antibody
Pathways associated with anti-ASCL1 antibody
Diseases associated with anti-ASCL1 antibody
Organs/Tissues associated with anti-ASCL1 antibody
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