BC032130
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,144 Da
NCBI Official Full Name
Homo sapiens asialoglycoprotein receptor 1, mRNA
NCBI Official Synonym Full Names
asialoglycoprotein receptor 1
NCBI Protein Information
asialoglycoprotein receptor 1
UniProt Protein Name
Asialoglycoprotein receptor 1
UniProt Synonym Protein Names
C-type lectin domain family 4 member H1; Hepatic lectin H1; HL-1
UniProt Synonym Gene Names
NCBI Summary for ASGR1
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
UniProt Comments for ASGR1
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Product References and Citations for anti-ASGR1 antibody
(1) Onizuka, T., Shimizu, H., Moriwaki, Y., et al. NMR study of ligand release from asialoglycoprotein receptor under solution conditions in early endosomes. FEBS J. 279 (15), 2645-2656 (2012).
Research Articles on ASGR1
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Products associated with anti-ASGR1 antibody
Pathways associated with anti-ASGR1 antibody
Diseases associated with anti-ASGR1 antibody
Organs/Tissues associated with anti-ASGR1 antibody
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