AAH69578.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ATOH1 protein
NCBI Official Synonym Full Names
atonal homolog 1 (Drosophila)
NCBI Protein Information
protein atonal homolog 1; helix-loop-helix protein hATH-1; class A basic helix-loop-helix protein 14
UniProt Protein Name
Protein atonal homolog 1
UniProt Synonym Protein Names
Class A basic helix-loop-helix protein 14; bHLHa14; Helix-loop-helix protein hATH-1
UniProt Synonym Gene Names
UniProt Entry Name
ATOH1_HUMAN
NCBI Summary for ATOH1
This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]
UniProt Comments for ATOH1
ATOH1: a conserved transcription factor that regulates secretory cell differentiation in colonic epithelium. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box- dependent transcription . Efficient DNA binding requires dimerization with another bHLH protein. Loss of ATOH1 expression in the colon of mice initiates colon cancer. ATOH1 has been silenced in most human colon cancers, and reactivation of this gene in cultured human colon cancer cells is anti-proliferative and induces apoptosis.
Protein type: Transcription factor; Cell development/differentiation; DNA-binding
Chromosomal Location of Human Ortholog: 4q22
Cellular Component: nucleus
Molecular Function: protein dimerization activity; chromatin DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; axon guidance; inner ear morphogenesis; central nervous system development; auditory receptor cell fate determination; neuron migration; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; positive regulation of auditory receptor cell differentiation; auditory receptor cell fate specification; positive regulation of neuron differentiation; negative regulation of apoptosis
Research Articles on ATOH1
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Products associated with anti-ATOH1 antibody
Diseases associated with anti-ATOH1 antibody
Organs/Tissues associated with anti-ATOH1 antibody
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