NP_000031.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,852 Da
NCBI Official Full Name
apolipoprotein C-III
NCBI Official Synonym Full Names
apolipoprotein C-III
NCBI Protein Information
apolipoprotein C-III; apo-CIII; apoC-III; apolipoprotein C3; OTTHUMP00000043270; OTTHUMP00000069353
UniProt Protein Name
Apolipoprotein C-III
UniProt Synonym Protein Names
Apolipoprotein C3
UniProt Entry Name
APOC3_HUMAN
NCBI Summary for Apo CIII
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq]
UniProt Comments for Apo CIII
Function: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
Subcellular location: Secreted.
Tissue specificity: Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.
Post-translational modification: O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan. Ref.9 Ref.10
Involvement in disease: Defects in APOC3 may be a cause of hyperalphalipoproteinemia (HYPALIP) [
MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). Ref.11
Sequence similarities: Belongs to the apolipoprotein C3 family.
Research Articles on Apo CIII
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-Apo CIII antibody
Diseases associated with anti-Apo CIII antibody
Organs/Tissues associated with anti-Apo CIII antibody
|