NP_115791.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
133,284 Da
NCBI Official Full Name
caspase recruitment domain-containing protein 11
NCBI Official Synonym Full Names
caspase recruitment domain family member 11
NCBI Official Synonym Symbols
PPBL; BENTA; BIMP3; IMD11; CARMA1 [Similar Products]
NCBI Protein Information
caspase recruitment domain-containing protein 11
UniProt Protein Name
Caspase recruitment domain-containing protein 11
UniProt Synonym Protein Names
CARD-containing MAGUK protein 1; Carma 1
UniProt Synonym Gene Names
UniProt Entry Name
CAR11_HUMAN
NCBI Summary for CARD11
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]
UniProt Comments for CARD11
CARD11: a CARD (caspase recruitment domain) protein that belongs to the membrane-associated guanylate kinase (MAGUK) family. MAGUK proteins function as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. Contains an N-terminal CARD domain, a central coiled-coil domain, and a C-terminal region containing a PDZ, an SH3, and a GUK. Its CARD domain associates with the CARD domain of BCL10. BCL10 activates NF-kappaB through the IkappaB kinase complex in response to upstream stimuli. Apparently activates NF-kappaB and induce the phosphorylation of BCL10. Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7p22
Cellular Component: cytoplasm; cytosol; immunological synapse; lipid raft; plasma membrane; T cell receptor complex
Molecular Function: CARD domain binding; guanylate kinase activity; protein binding
Biological Process: activation of NF-kappaB transcription factor; GDP metabolic process; GMP metabolic process; positive regulation of B cell proliferation; positive regulation of cytokine production; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-2 biosynthetic process; positive regulation of T cell proliferation; regulation of apoptosis; regulation of B cell differentiation; regulation of T cell differentiation; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; T cell receptor signaling pathway; thymic T cell selection
Disease: B-cell Expansion With Nfkb And T-cell Anergy; Immunodeficiency 11; Persistent Polyclonal B-cell Lymphocytosis
Research Articles on CARD11
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Products associated with anti-CARD11 antibody
Pathways associated with anti-CARD11 antibody
Diseases associated with anti-CARD11 antibody
Disease Name |
Pubmed Publications |
Lymphoma, Large B-Cell, Diffuse Antibodies |
>59 publications with CARD11 and Lymphoma, Large B-Cell, Diffuse |
Inflammation Antibodies |
>18 publications with CARD11 and Inflammation |
Necrosis Antibodies |
>8 publications with CARD11 and Necrosis |
Chromosome Aberrations Antibodies |
>8 publications with CARD11 and Chromosome Aberrations |
Lung Diseases Antibodies |
>5 publications with CARD11 and Lung Diseases |
Cell Transformation, Neoplastic Antibodies |
>4 publications with CARD11 and Cell Transformation, Neoplastic |
Leukemia-Lymphoma, Adult T-Cell Antibodies |
>4 publications with CARD11 and Leukemia-Lymphoma, Adult T-Cell |
Breast Neoplasms Antibodies |
>4 publications with CARD11 and Breast Neoplasms |
Sezary Syndrome Antibodies |
>3 publications with CARD11 and Sezary Syndrome |
Neoplasms, Experimental Antibodies |
>3 publications with CARD11 and Neoplasms, Experimental |
Organs/Tissues associated with anti-CARD11 antibody
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