O00257
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
CBX4 protein
NCBI Official Synonym Full Names
chromobox homolog 4
NCBI Official Synonym Symbols
NCBI Protein Information
E3 SUMO-protein ligase CBX4; OTTHUMP00000197308; OTTHUMP00000197309; Pc class 2 homolog; polycomb 2 homolog; NS5ATP1-binding protein 16; chromobox protein homolog 4; chromobox homolog 4 (Pc class homolog, Drosophila)
UniProt Protein Name
E3 SUMO-protein ligase CBX4
UniProt Synonym Protein Names
Chromobox protein homolog 4; Polycomb 2 homolog
UniProt Entry Name
CBX4_HUMAN
UniProt Comments for CBX4
CBX4: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor; SUMO ligase; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: nucleoplasm; nuclear speck; PcG protein complex; nucleus
Molecular Function: protein binding; enzyme binding; single-stranded RNA binding; SUMO binding; phosphoprotein binding; chromatin binding; transcription corepressor activity; methylated histone residue binding; ligase activity
Biological Process: protein sumoylation; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
Research Articles on CBX4
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Products associated with anti-CBX4 antibody
Pathways associated with anti-CBX4 antibody
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