NP_001025459.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
95/115/135 kDa (dependent upon the extent of glyco
NCBI Official Full Name
leukosialin
NCBI Official Synonym Full Names
sialophorin
NCBI Protein Information
leukosialin; galactoglycoprotein; leukocyte sialoglycoprotein; sialophorin (gpL115, leukosialin, CD43)
UniProt Protein Name
Leukosialin
UniProt Synonym Protein Names
Galactoglycoprotein; GALGP; Leukocyte sialoglycoprotein; Sialophorin; CD_antigen: CD43
UniProt Synonym Gene Names
UniProt Entry Name
LEUK_HUMAN
NCBI Summary for CD43
The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011]
UniProt Comments for CD43
sialophorin: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1. During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response. Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX. Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
Protein type: Membrane protein, integral; Cell surface
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: extracellular space; cell surface; membrane; integral to plasma membrane; plasma membrane; basement membrane; uropod; external side of plasma membrane
Molecular Function: protein binding; transmembrane receptor activity
Biological Process: positive regulation of tumor necrosis factor biosynthetic process; regulation of defense response to virus; establishment and/or maintenance of cell polarity; negative regulation of cell adhesion; signal transduction; chemotaxis; negative thymic T cell selection; cell surface receptor linked signal transduction; negative regulation of T cell proliferation; response to protozoan; defense response to bacterium; T cell costimulation; cellular defense response; positive regulation of T cell proliferation; immune response; positive regulation of protein amino acid phosphorylation; negative regulation of type IV hypersensitivity; blood coagulation; leukocyte migration
Research Articles on CD43
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Products associated with anti-CD43 antibody
Pathways associated with anti-CD43 antibody
Diseases associated with anti-CD43 antibody
Organs/Tissues associated with anti-CD43 antibody
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