NP_001299.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
carboxypeptidase N catalytic chain
NCBI Official Synonym Full Names
carboxypeptidase N, polypeptide 1
NCBI Official Synonym Symbols
NCBI Protein Information
carboxypeptidase N catalytic chain; kininase I; kininase-1; carboxypeptidase K; lysine carboxypeptidase; serum carboxypeptidase N; anaphylatoxin inactivator; arginine carboxypeptidase; plasma carboxypeptidase B; carboxypeptidase N small subunit; carboxypeptidase N catalytic subunit; carboxypeptidase N polypeptide 1 50 kD
UniProt Protein Name
Carboxypeptidase N catalytic chain
UniProt Synonym Protein Names
Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; Serum carboxypeptidase N
UniProt Synonym Gene Names
UniProt Entry Name
CBPN_HUMAN
NCBI Summary for CPN1
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]
UniProt Comments for CPN1
CPN1: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND). Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder. Belongs to the peptidase M14 family.
Protein type: Secreted; EC 3.4.17.3; Secreted, signal peptide; Protease
Chromosomal Location of Human Ortholog: 10q24.2
Cellular Component: extracellular space
Molecular Function: zinc ion binding; metallocarboxypeptidase activity
Biological Process: response to glucocorticoid stimulus; proteolysis
Disease: Carboxypeptidase N Deficiency
Research Articles on CPN1
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Products associated with anti-CPN1 antibody
Pathways associated with anti-CPN1 antibody
Diseases associated with anti-CPN1 antibody
Organs/Tissues associated with anti-CPN1 antibody
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