P34998
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
corticotropin releasing hormone receptor 1
NCBI Official Synonym Full Names
corticotropin releasing hormone receptor 1
NCBI Official Synonym Symbols
CRF1; CRHR; CRF-R; CRFR1; CRF-R1; CRFR-1; CRH-R1; CRHR1L; CRHR1f; CRF-R-1; CRH-R-1; CRH-R1h [Similar Products]
NCBI Protein Information
corticotropin-releasing factor receptor 1; seven transmembrane helix receptor; corticotropin-releasing hormone receptor 1; corticotropin-releasing factor type 1 receptor
UniProt Protein Name
Corticotropin-releasing factor receptor 1
UniProt Synonym Protein Names
Corticotropin-releasing hormone receptor 1
UniProt Synonym Gene Names
UniProt Entry Name
CRFR1_HUMAN
NCBI Summary for CRHR1
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants one of which is a non-coding read-through transcript with the neighboring gene MGC57346.
UniProt Comments for CRHR1
CRF-R1: a G-protein coupled receptor that specifically binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. Four splice-variant isoforms have been described.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: multivesicular body; cell soma; apical part of cell; integral to plasma membrane; dendrite; integral to membrane; plasma membrane; trans-Golgi network; intrinsic to plasma membrane; vesicle
Molecular Function: protein binding; corticotropin-releasing hormone binding; corticotropin-releasing hormone receptor activity; protein complex binding; G-protein alpha-subunit binding; corticotrophin-releasing factor receptor activity
Biological Process: fear response; hypothalamus development; hormone-mediated signaling; adrenal gland development; adenylate cyclase activation; positive regulation of mast cell degranulation; behavioral response to ethanol; female pregnancy; memory; behavioral response to pain; elevation of cytosolic calcium ion concentration; general adaptation syndrome, behavioral process; epithelial cell differentiation; neuropeptide signaling pathway; behavioral response to cocaine; adrenocorticotropin hormone secretion; negative regulation of epinephrine secretion; response to hypoxia; visual learning; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune response; parturition; response to electrical stimulus
Research Articles on CRHR1
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Products associated with anti-CRHR1 antibody
Pathways associated with anti-CRHR1 antibody
Diseases associated with anti-CRHR1 antibody
Organs/Tissues associated with anti-CRHR1 antibody
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