NP_000769.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cytochrome P450 4A11
NCBI Official Synonym Full Names
cytochrome P450, family 4, subfamily A, polypeptide 11
NCBI Protein Information
cytochrome P450 4A11; CYPIVA11; P450HL-omega; 20-HETE synthase; OTTHUMP00000009714; OTTHUMP00000009715; alkane-1 monooxygenase; cytochrome P450HL-omega; cytochrome P-450HK-omega; fatty acid omega-hydroxylase; lauric acid omega-hydroxylase; 20-hydroxyeicosatetraenoic acid synthase; cytochrome P450, subfamily IVA, polypeptide 11
UniProt Protein Name
Cytochrome P450 4A11
UniProt Synonym Protein Names
20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; CYP4AII; CYPIVA11; Cytochrome P-450HK-omega; Cytochrome P450HL-omega; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase
UniProt Synonym Gene Names
UniProt Entry Name
CP4AB_HUMAN
NCBI Summary for CYP4A11
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq]
UniProt Comments for CYP4A11
CYP4A11: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cofactor and Vitamin Metabolism - retinol; Lipid Metabolism - arachidonic acid; Endoplasmic reticulum; EC 1.14.15.3; Oxidoreductase; Lipid Metabolism - fatty acid
Chromosomal Location of Human Ortholog: 1p33
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm; apical plasma membrane
Molecular Function: leukotriene-B4 20-monooxygenase activity; iron ion binding; heme binding; arachidonic acid epoxygenase activity; alkane 1-monooxygenase activity
Biological Process: xenobiotic metabolic process; positive regulation of icosanoid secretion; arachidonic acid metabolic process; renal water homeostasis; sodium ion homeostasis; leukotriene metabolic process; epoxygenase P450 pathway; long-chain fatty acid metabolic process; cellular lipid metabolic process; fatty acid metabolic process; pressure natriuresis
Research Articles on CYP4A11
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Pathways associated with anti-CYP4A11 antibody
Diseases associated with anti-CYP4A11 antibody
Organs/Tissues associated with anti-CYP4A11 antibody
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