NP_001887.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
casein kinase II subunit alpha'
NCBI Official Synonym Full Names
casein kinase 2 alpha 2
NCBI Protein Information
casein kinase II subunit alpha'
UniProt Protein Name
Casein kinase II subunit alpha'
UniProt Synonym Gene Names
UniProt Entry Name
CSK22_HUMAN
UniProt Comments for CSNK2A2
CK2A2: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Other group; CK2 family
Chromosomal Location of Human Ortholog: 16q21
Cellular Component: cytosol; nucleus; PcG protein complex
Molecular Function: ATP binding; protein binding; protein N-terminus binding; protein serine/threonine kinase activity
Biological Process: apoptosis; axon guidance; mitotic cell cycle; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; Wnt receptor signaling pathway
Research Articles on CSNK2A2
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Products associated with anti-CSNK2A2 antibody
Pathways associated with anti-CSNK2A2 antibody
Diseases associated with anti-CSNK2A2 antibody
Organs/Tissues associated with anti-CSNK2A2 antibody
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