CAA30428.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cathepsin H, partial
NCBI Official Synonym Full Names
cathepsin H
NCBI Official Synonym Symbols
ACC4; ACC5; CPSB; ACC-4; ACC-5; minichain [Similar Products]
NCBI Protein Information
pro-cathepsin H
UniProt Protein Name
Pro-cathepsin H
UniProt Synonym Gene Names
UniProt Entry Name
CATH_HUMAN
NCBI Summary for CTSH
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. [provided by RefSeq, Mar 2010]
UniProt Comments for CTSH
CTSH: Important for the overall degradation of proteins in lysosomes. Belongs to the peptidase C1 family.
Protein type: Protease; EC 3.4.22.16
Chromosomal Location of Human Ortholog: 15q25.1
Cellular Component: extracellular space; lysosome; acrosome; cytosol; outer dense fiber
Molecular Function: peptidase activity; protein binding; protein self-association; HLA-A specific activating MHC class I receptor activity; serine-type endopeptidase activity; cysteine-type endopeptidase activity; endopeptidase activity; protein complex binding; caspase activator activity; kininogen binding; aminopeptidase activity; cysteine-type peptidase activity
Biological Process: caspase activation; adaptive immune response; response to retinoic acid; protein destabilization; membrane protein proteolysis; proteolysis; antigen processing and presentation; positive regulation of angiogenesis; positive regulation of cell proliferation; zymogen activation; spermatogenesis; surfactant homeostasis; metanephros development; immune response-regulating signal transduction; positive regulation of cell migration; T cell mediated cytotoxicity; negative regulation of apoptosis
Research Articles on CTSH
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Products associated with anti-CTSH antibody
Pathways associated with anti-CTSH antibody
Diseases associated with anti-CTSH antibody
Organs/Tissues associated with anti-CTSH antibody
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