NP_001934
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
116.7kDa
NCBI Official Full Name
desmoglein-2 preproprotein
NCBI Official Synonym Full Names
desmoglein 2
NCBI Official Synonym Symbols
HDGC; CDHF5; ARVC10; ARVD10; CMD1BB [Similar Products]
NCBI Protein Information
desmoglein-2
UniProt Protein Name
Desmoglein-2
UniProt Synonym Protein Names
Cadherin family member 5; HDGC
UniProt Synonym Gene Names
UniProt Entry Name
DSG2_HUMAN
NCBI Summary for DSG2
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jul 2008]
UniProt Comments for DSG2
DSG2: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10); also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB). A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Protein type: Calcium-binding; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 18q12.1
Cellular Component: desmosome; cell surface; apical plasma membrane; integral to membrane; plasma membrane; intercellular junction; lateral plasma membrane
Molecular Function: calcium ion binding
Biological Process: maternal process involved in pregnancy; apoptosis; cell adhesion; homophilic cell adhesion; response to progesterone stimulus; cell structure disassembly during apoptosis
Disease: Cardiomyopathy, Dilated, 1bb; Arrhythmogenic Right Ventricular Dysplasia, Familial, 10
Research Articles on DSG2
Precautions
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Products associated with anti-DSG2 antibody
Pathways associated with anti-DSG2 antibody
Diseases associated with anti-DSG2 antibody
Disease Name |
Pubmed Publications |
Heart Defects, Congenital Antibodies |
>46 publications with DSG2 and Heart Defects, Congenital |
Disease Models, Animal Antibodies |
>8 publications with DSG2 and Disease Models, Animal |
Neoplasms, Experimental Antibodies |
>7 publications with DSG2 and Neoplasms, Experimental |
Necrosis Antibodies |
>7 publications with DSG2 and Necrosis |
Neoplasm Metastasis Antibodies |
>6 publications with DSG2 and Neoplasm Metastasis |
Inflammation Antibodies |
>5 publications with DSG2 and Inflammation |
Breast Neoplasms Antibodies |
>5 publications with DSG2 and Breast Neoplasms |
Arrhythmogenic Right Ventricular Dysplasia, Familial, 10 Antibodies |
>5 publications with DSG2 and Arrhythmogenic Right Ventricular Dysplasia, Familial, 10 |
Hypertrophy Antibodies |
>4 publications with DSG2 and Hypertrophy |
Fibrosis Antibodies |
>4 publications with DSG2 and Fibrosis |
Organs/Tissues associated with anti-DSG2 antibody
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