NP_058637.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
delta-like protein 3 isoform 1
NCBI Official Synonym Full Names
delta-like 3 (Drosophila)
NCBI Official Synonym Symbols
NCBI Protein Information
delta-like protein 3; delta3; drosophila Delta homolog 3
UniProt Protein Name
Delta-like protein 3
UniProt Synonym Protein Names
Drosophila Delta homolog 3
UniProt Synonym Gene Names
UniProt Entry Name
DLL3_HUMAN
NCBI Summary for DLL3
This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for DLL3
DLL3: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Can bind and activate Notch-1 or another Notch receptor.
Protein type: Membrane protein, integral; Cell development/differentiation
Chromosomal Location of Human Ortholog: 19q13
Cellular Component: integral to membrane
Molecular Function: Notch binding
Biological Process: paraxial mesoderm development; compartment specification; somitogenesis; Notch signaling pathway; skeletal development; negative regulation of neurogenesis
Disease: Spondylocostal Dysostosis 1, Autosomal Recessive
Research Articles on DLL3
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Products associated with anti-DLL3 antibody
Pathways associated with anti-DLL3 antibody
Diseases associated with anti-DLL3 antibody
Organs/Tissues associated with anti-DLL3 antibody
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