NP_001372.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
docking protein 1 isoform 1
NCBI Official Synonym Full Names
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
NCBI Protein Information
docking protein 1; pp62; p62(dok); OTTHUMP00000160414; OTTHUMP00000202719; Downstream of tyrosine kinase 1; docking protein 1 (downstream of tyrosine kinase 1)
UniProt Protein Name
Docking protein 1 variant
UniProt Entry Name
Q53GP8_HUMAN
NCBI Summary for DOK1
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
UniProt Comments for DOK1
DOK1: a docking protein that interacts with receptor tyrosine kinases. It is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2p13
Cellular Component: perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; receptor signaling protein activity; insulin receptor binding
Biological Process: cell surface receptor linked signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Product References and Citations for anti-DOK1 antibody
• Noguchi, T. et al. (1999) EMBOJ 18(7):1748. • Kashige, N. et al. (2000) Proc. Nat. Acad. Sci. 97(5):2093. • Lee, S. et al. (2004) Proc. Nat. Acad. Sci. 101(50):17416. • Woodring, P.J. (2004) J Cell Biol. 165(4):493.
Research Articles on DOK1
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Products associated with anti-DOK1 antibody
Pathways associated with anti-DOK1 antibody
Diseases associated with anti-DOK1 antibody
Organs/Tissues associated with anti-DOK1 antibody
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