NP_001035548.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
107,841 Da
NCBI Official Full Name
endoplasmic reticulum aminopeptidase 1 isoform b
NCBI Official Synonym Full Names
endoplasmic reticulum aminopeptidase 1
NCBI Official Synonym Symbols
ALAP; A-LAP; ARTS1; ERAAP; APPILS; ARTS-1; ERAAP1; PILSAP; PILS-AP [Similar Products]
NCBI Protein Information
endoplasmic reticulum aminopeptidase 1; aminopeptidase PILS; adipocyte-derived leucine aminopeptidase; aminopeptidase regulator of TNFR1 shedding; puromycin-insensitive leucyl-specific aminopeptidase; endoplasmic reticulum aminopeptidase 1 delta-Exon-11 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-13 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-14 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-15 isoform; endoplasmic reticulum aminopeptidase associated with antigen processing; type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
UniProt Protein Name
Endoplasmic reticulum aminopeptidase 1
UniProt Synonym Protein Names
ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
UniProt Synonym Gene Names
UniProt Entry Name
ERAP1_HUMAN
NCBI Summary for ERAP1
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
UniProt Comments for ERAP1
ARTS1: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. Belongs to the peptidase M1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.11.-; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q15
Cellular Component: extracellular space; endoplasmic reticulum membrane; membrane; endoplasmic reticulum lumen; endoplasmic reticulum; extracellular region; integral to membrane; cytosol
Molecular Function: protein binding; interleukin-6 receptor binding; metalloexopeptidase activity; interleukin-1, Type II receptor binding; zinc ion binding; aminopeptidase activity
Biological Process: fat cell differentiation; positive regulation of angiogenesis; antigen processing and presentation of peptide antigen via MHC class I; response to bacterium; regulation of blood pressure; membrane protein ectodomain proteolysis; angiogenesis; antigen processing and presentation of endogenous peptide antigen via MHC class I; regulation of innate immune response
Research Articles on ERAP1
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Products associated with anti-ERAP1 antibody
Pathways associated with anti-ERAP1 antibody
Diseases associated with anti-ERAP1 antibody
Organs/Tissues associated with anti-ERAP1 antibody
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