View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-ELK1 antibody :: Rabbit Elk1 Polyclonal Antibody Catalog # MBS628161 Unit / Price 0.05 mg / $490 +1 FREE 8GB USB 5x0.05 mg / $2,020 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Elk1, Polyclonal Antibody Full Product Name Elk1, phosphorylated (Ser383) (ETS Domain-containing Protein Elk-1) Product Synonym Names Anti -Elk1, phosphorylated (Ser383) (ETS Domain-containing Protein Elk-1) Product Gene Name anti-ELK1 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Chromosome Location Chromosome: X; NC_000023.10 (47494920..47510003, complement). Location: Xp11.2 OMIM 311040 3D Structure ModBase 3D Structure for P19419 Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human, Mouse, Rat Specificity Recognizes human EIk1 when phosphorylated at serine 383. Species Cross-Reactivity: mouse, rat. Purity/Purification Affinity PurifiedPurified by immunoaffinity chromatography. Form/Format Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol. Immunogen Synthetic phosphopeptide corresponding to human Elk-1around the phosphorylation site of serine 383 (T-L-SP-P-I). Preparation and Storage May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Other Notes Small volumes of anti-ELK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-ELK1 antibody Elk-1 is a transcription factor that is part of the ets oncogene superfamily. Elk-1 forms a ternary complex with the serum response factors, SRE and SRF, mediating gene activity in response to serum and growth factors. Activation by several mitogen-activated protein kinases (Erk1 and Erk2) mediates the immediate early responses of the c-fos promoter to growth factors and other stimuli. Serines 383 and 389 in the C-terminal region are the preferred sites for phosphorylation-induced activation. Product Categories/Family for anti-ELK1 antibody Antibodies; Abs to Transcription Factors Applications Tested/Suitable for anti-ELK1 antibody Western Blot (WB), Immunohistochemistry (IHC) Application Notes for anti-ELK1 antibody Suitable for use in Western Blot and Immunohistochemistry.Dilution: Western Blot: 1:500-1:1,000Immunohistochemistry: 1:50-1:100 TOP NCBI/Uniprot data below describe general gene information for ELK1. It may not necessarily be applicable to this product. NCBI GI # 4126584 NCBI GeneID 2002 UniProt Primary Accession # P19419 [Other Products] UniProt Secondary Accession # O75606; O95058; Q969X8; Q9UJM4; B2R7H4[Other Products] UniProt Related Accession # P19419; Q59GR2; Q6FG56; Q86SR6; Q8N9S0[Other Products] Molecular Weight 44,888 Da[Similar Products] TOP NCBI Official Full Name elk1 NCBI Official Synonym Full Names ELK1, member of ETS oncogene family NCBI Official Symbol ELK1 [Similar Products] NCBI Protein Information ETS domain-containing protein Elk-1; ETS-like gene 1; OTTHUMP00000023224; OTTHUMP00000023225 UniProt Protein Name ETS domain-containing protein Elk-1 Protein Family ETS domain-containing protein UniProt Gene Name ELK1 [Similar Products] UniProt Entry Name ELK1_HUMAN TOP NCBI Summary for ELK1 This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] TOP UniProt Comments for ELK1 ELK1: a transcription factor of the Ets family and the ternary complex factor (TCF) subfamily. Forms a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. Mediates gene activity in response to serum and growth factors. Phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus; phosphorylation at these sites is critical for transcriptional activation by Elk-1. Two alternatively-spliced isoforms have been described.Protein type: DNA-binding; Transcription factorChromosomal Location of Human Ortholog: Xp11.2Cellular Component: nucleoplasm; cell soma; mitochondrion; dendrite; nerve terminal; nucleusMolecular Function: protein binding; double-stranded DNA binding; chromatin binding; transcription factor activityBiological Process: transcription from RNA polymerase II promoter; response to light stimulus; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; cell differentiation; toll-like receptor 4 signaling pathway Research Articles on ELK1 1. AC3-33 is a novel member of the secretory family and inhibits Elk1 transcriptional activity via ERK1/2 MAP TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-ELK1 antibody Reference Product PubMed Publications MAPK3 antibody >103 publications with ELK1 and MAPK3 SRF antibody >64 publications with ELK1 and SRF MAP2K1 antibody >17 publications with ELK1 and MAP2K1 GRB2 antibody >12 publications with ELK1 and GRB2 MAPK8 antibody >5 publications with ELK1 and MAPK8 CREBBP antibody >3 publications with ELK1 and CREBBP BRCA1 antibody >2 publications with ELK1 and BRCA1 SNCA antibody >2 publications with ELK1 and SNCA MAPK14 antibody >2 publications with ELK1 and MAPK14 KLF4 antibody >2 publications with ELK1 and KLF4 Pathways associated with anti-ELK1 antibody Products by Pathway Pathway Diagram Activated TLR4 Signalling Pathway antibodies Activated TLR4 Signalling Pathway Diagram Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram B Cell Receptor Signaling Pathway antibodies B Cell Receptor Signaling Pathway Diagram BCR Signaling Pathway antibodies BCR Signaling Pathway Diagram Downstream Signaling In Naive CD8+ T Cells Pathway antibodies Downstream Signaling In Naive CD8+ T Cells Pathway Diagram EGFR1 Signaling Pathway antibodies EGFR1 Signaling Pathway Diagram ERK/MAPK Targets Pathway antibodies ERK/MAPK Targets Pathway Diagram Endometrial Cancer Pathway antibodies Endometrial Cancer Pathway Diagram Endometrial Cancer Pathway antibodies Endometrial Cancer Pathway Diagram ErbB Signaling Pathway antibodies ErbB Signaling Pathway Diagram Diseases associated with anti-ELK1 antibody Disease Name Pubmed Publications Neoplasms Antibodies >92 publications with ELK1 and Neoplasms Carcinoma Antibodies >27 publications with ELK1 and Carcinoma Urogenital Neoplasms Antibodies >19 publications with ELK1 and Urogenital Neoplasms Adenocarcinoma Antibodies >18 publications with ELK1 and Adenocarcinoma Vascular Diseases Antibodies >17 publications with ELK1 and Vascular Diseases Leukemia Antibodies >16 publications with ELK1 and Leukemia Endocrine Gland Neoplasms Antibodies >16 publications with ELK1 and Endocrine Gland Neoplasms Cardiovascular Diseases Antibodies >16 publications with ELK1 and Cardiovascular Diseases Cell Transformation, Neoplastic Antibodies >16 publications with ELK1 and Cell Transformation, Neoplastic Translocation, Genetic Antibodies >13 publications with ELK1 and Translocation, Genetic Organs/Tissues associated with anti-ELK1 antibody Organ/Tissue Name Pubmed Publications Brain Antibodies >88 publications with ELK1 and Brain Blood Antibodies >55 publications with ELK1 and Blood Lung Antibodies >25 publications with ELK1 and Lung Ovary Antibodies >17 publications with ELK1 and Ovary Embryonic Tissue Antibodies >17 publications with ELK1 and Embryonic Tissue Bone Antibodies >12 publications with ELK1 and Bone Prostate Antibodies >10 publications with ELK1 and Prostate Liver Antibodies >10 publications with ELK1 and Liver Skin Antibodies >8 publications with ELK1 and Skin Pancreas Antibodies >7 publications with ELK1 and Pancreas TOP © 2006-24 MyBioSource.com. 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