NP_001441.4
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,890 Da
NCBI Official Full Name
four and a half LIM domains protein 2 isoform a
NCBI Official Synonym Full Names
four and a half LIM domains 2
NCBI Official Synonym Symbols
DRAL; AAG11; FHL-2; SLIM3; SLIM-3 [Similar Products]
NCBI Protein Information
four and a half LIM domains protein 2
UniProt Protein Name
Four and a half LIM domains protein 2
UniProt Synonym Protein Names
LIM domain protein DRAL; Skeletal muscle LIM-protein 3; SLIM-3
UniProt Synonym Gene Names
UniProt Entry Name
FHL2_HUMAN
NCBI Summary for FHL2
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]
UniProt Comments for FHL2
FHL2: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q12.2
Cellular Component: actin cytoskeleton; focal adhesion; M band; nucleoplasm; nucleus; Z disc
Molecular Function: androgen receptor binding; identical protein binding; protein binding; transcription coactivator activity; transcription factor binding; zinc ion binding
Biological Process: androgen receptor signaling pathway; atrial cardiac muscle cell development; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; osteoblast differentiation; positive regulation of transcription, DNA-dependent; response to hormone stimulus; transcription, DNA-dependent; ventricular cardiac muscle cell development
Research Articles on FHL2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-FHL2 antibody
Pathways associated with anti-FHL2 antibody
Diseases associated with anti-FHL2 antibody
Organs/Tissues associated with anti-FHL2 antibody
|