Q9UKA2.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,097 Da
NCBI Official Full Name
F-box/LRR-repeat protein 4
NCBI Official Synonym Full Names
F-box and leucine-rich repeat protein 4
NCBI Protein Information
F-box/LRR-repeat protein 4
UniProt Protein Name
F-box/LRR-repeat protein 4
UniProt Synonym Protein Names
F-box and leucine-rich repeat protein 4; F-box protein FBL4/FBL5
UniProt Synonym Gene Names
UniProt Entry Name
FBXL4_HUMAN
NCBI Summary for FBXL4
This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for FBXL4
FBXL4: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
Chromosomal Location of Human Ortholog: 6q16.1-q16.3
Cellular Component: nucleoplasm; mitochondrial intermembrane space; ubiquitin ligase complex
Biological Process: ubiquitin-dependent protein catabolic process
Disease: Mitochondrial Dna Depletion Syndrome 13 (encephalomyopathic Type)
Research Articles on FBXL4
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Products associated with anti-FBXL4 antibody
Diseases associated with anti-FBXL4 antibody
Organs/Tissues associated with anti-FBXL4 antibody
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