NP_032072.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
follistatin isoform 2
NCBI Official Synonym Full Names
follistatin
NCBI Official Synonym Symbols
NCBI Protein Information
follistatin
UniProt Protein Name
Follistatin
UniProt Synonym Protein Names
Activin-binding protein
UniProt Synonym Gene Names
UniProt Entry Name
FST_MOUSE
NCBI Summary for Fst
The protein encoded by this gene binds to and negatively regulates activin, as well as other members of the transforming growth factor beta family, and acts to prevent uncontrolled cellular proliferation. This protein also contains a heparin-binding sequence. It is expressed in many of the tissues in which activin is synthesized and is thought to clear activin from the circulation by attachment to the cell surface. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms, including FST315 and FST288, that differ at their C-terminus. Another isoform, FST303 is thought to be produced by proteolytic cleavage of FST315. These isoforms differ in their localization and in their ability to bind heparin. While FST315 is a circulating protein, FST288 is tissue-bound, and FST303 is gonad-specific. While deletion of all isoforms results in embryonic lethality, expression of just FST288 is sufficient for embryonic development, but the resultant mice have fertility defects. [provided by RefSeq, Aug 2014]
UniProt Comments for Fst
FST: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH)
Protein type: Secreted, signal peptide; Secreted
Cellular Component: cytoplasm; extracellular region; nucleus
Molecular Function: heparan sulfate proteoglycan binding; activin binding
Biological Process: hair follicle morphogenesis; keratinocyte proliferation; negative regulation of transcription from RNA polymerase II promoter; pattern specification process; odontogenesis of dentine-containing teeth; BMP signaling pathway; positive regulation of hair follicle development; negative regulation of activin receptor signaling pathway; negative regulation of cell differentiation; gamete generation; hemopoietic progenitor cell differentiation; skeletal development; female gonad development
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Products associated with anti-Fst antibody
Pathways associated with anti-Fst antibody
Diseases associated with anti-Fst antibody
Organs/Tissues associated with anti-Fst antibody
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