NP_058761.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
gamma-aminobutyric acid receptor subunit beta-3
NCBI Official Synonym Full Names
gamma-aminobutyric acid (GABA) A receptor, beta 3
NCBI Protein Information
gamma-aminobutyric acid receptor subunit beta-3; GABA(A) receptor subunit beta-3; Gamma-aminobutyric acid receptor beta 3; gamma-aminobutyric acid receptor, subunit beta 3; testis gamma-aminobutyric acid receptor subunit beta 3; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit beta-3
UniProt Synonym Protein Names
GABA(A) receptor subunit beta-3
UniProt Synonym Gene Names
UniProt Entry Name
GBRB3_RAT
NCBI Summary for GABRB3
beta 3 subunit, with alpha subunits forms active GABA-A receptors [RGD, Feb 2006]
UniProt Comments for GABRB3
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subunit structure: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1.
Subcellular location: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence similarities: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily. [View classification]
Product References and Citations for anti-GABRB3 antibody
• Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ (2003) A kinase anchoring protein 79/150 facilitates the phosphorylation of GABAA receptors by cAMP-dependent protein kinase via selective interaction with receptor beta-subunits. Mol Cell Neurosci 22:87-97. • McKernan RM, et al. (2000) Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor alpha1-subtype. Nature Neurosci 3:587-592. • Mehta AK, Ticku MK (1998) Prevalence of the GABAA receptor assemblies containing alpha1-subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: Lack of modulation by chronic ethanol administration. Mol Brain Res 67:194-199. • Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart W (2004) Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABAA receptor gamma2-subunit. Biochem Pharmacol 68:1621-1629. • Olsen RW, Tobin AJ (1990) Molecular biology of GABAA receptors. FASEB 4:1469-1480.
Research Articles on GABRB3
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Products associated with anti-GABRB3 antibody
Pathways associated with anti-GABRB3 antibody
Diseases associated with anti-GABRB3 antibody
Organs/Tissues associated with anti-GABRB3 antibody
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