NP_005449.5
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
105,821 Da
NCBI Official Full Name
gamma-aminobutyric acid type B receptor subunit 2
NCBI Official Synonym Full Names
gamma-aminobutyric acid (GABA) B receptor, 2
NCBI Official Synonym Symbols
HG20; GPR51; GPRC3B; GABABR2; HRIHFB2099 [Similar Products]
NCBI Protein Information
gamma-aminobutyric acid type B receptor subunit 2
UniProt Protein Name
Gamma-aminobutyric acid type B receptor subunit 2
UniProt Synonym Protein Names
G-protein coupled receptor 51; HG20
UniProt Synonym Gene Names
GPR51; GPRC3B; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2 [Similar Products]
UniProt Entry Name
GABR2_HUMAN
NCBI Summary for GABABR2
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]
UniProt Comments for GABABR2
GABBR2: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region. Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
Protein type: GPCR, family 3; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 9q22.1-q22.3
Cellular Component: postsynaptic membrane; neuron projection; integral to plasma membrane; cytoplasm; plasma membrane; cell junction
Molecular Function: protein binding; GABA-B receptor activity
Biological Process: synaptic transmission; G-protein coupled receptor protein signaling pathway; negative regulation of adenylate cyclase activity; gamma-aminobutyric acid signaling pathway
Disease: Tobacco Addiction, Susceptibility To
Research Articles on GABABR2
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Products associated with anti-GABABR2 antibody
Pathways associated with anti-GABABR2 antibody
Diseases associated with anti-GABABR2 antibody
Organs/Tissues associated with anti-GABABR2 antibody
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